Document Detail

Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
MedLine Citation:
PMID:  22895435     Owner:  NLM     Status:  MEDLINE    
The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.
Georg Halder; Sirio Dupont; Stefano Piccolo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-16
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  13     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-30     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-600     Citation Subset:  IM    
Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
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MeSH Terms
Adaptor Proteins, Signal Transducing / metabolism*
Cell Adhesion
Cell Differentiation
Cell Shape
Cellular Microenvironment
Cytoskeleton / metabolism*
Extracellular Matrix / metabolism
Intracellular Signaling Peptides and Proteins / metabolism*
Mechanotransduction, Cellular*
Mesenchymal Stromal Cells / metabolism
Models, Biological
Nuclear Proteins / metabolism*
Phosphoproteins / metabolism*
Stress, Mechanical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/Phosphoproteins; 0/WWTR1 protein, human; 0/YAP1 (Yes-associated) protein, human

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