| Transduction of mechanical and cytoskeletal cues by YAP and TAZ. | |
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MedLine Citation:
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PMID: 22895435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour. |
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Authors:
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Georg Halder; Sirio Dupont; Stefano Piccolo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-08-16 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 13 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-24 Completed Date: 2012-10-30 Revised Date: 2013-05-01 |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 591-600 Citation Subset: IM |
Affiliation:
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Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism* Animals Apoptosis Cell Adhesion Cell Differentiation Cell Shape Cellular Microenvironment Cytoskeleton / metabolism* Extracellular Matrix / metabolism Humans Mechanotransduction, Cellular* Mesenchymal Stromal Cells / metabolism Models, Biological Nuclear Proteins / metabolism* Phosphoproteins / metabolism* Stress, Mechanical Transcription Factors / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Nuclear Proteins; 0/Phosphoproteins; 0/TAZ protein, human; 0/Transcription Factors; 0/YAP1 (Yes-associated) protein, human |
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