Document Detail


Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
MedLine Citation:
PMID:  22895435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.
Authors:
Georg Halder; Sirio Dupont; Stefano Piccolo
Related Documents :
21949415 - Actin and microtubules drive differential aspects of planar cell polarity in multicilia...
21829575 - Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma...
22004535 - Selective detection of viable helicobacter pylori using ethidium monoazide or propidium...
2416585 - Evidence for two types of gaba-containing interneurons in the a-laminae of the cat late...
10198195 - Expression of clcn voltage-gated chloride channel genes in human blood vessels.
19447605 - Role of polarized cell divisions in zebrafish neural tube formation.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-16
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  13     ISSN:  1471-0080     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-30     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-600     Citation Subset:  IM    
Affiliation:
Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Apoptosis
Cell Adhesion
Cell Differentiation
Cell Shape
Cellular Microenvironment
Cytoskeleton / metabolism*
Extracellular Matrix / metabolism
Humans
Intracellular Signaling Peptides and Proteins / metabolism*
Mechanotransduction, Cellular*
Mesenchymal Stromal Cells / metabolism
Models, Biological
Nuclear Proteins / metabolism*
Phosphoproteins / metabolism*
Stress, Mechanical
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/Phosphoproteins; 0/WWTR1 protein, human; 0/YAP1 (Yes-associated) protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The super elongation complex (SEC) family in transcriptional control.
Next Document:  Association of regional body composition with bone mineral density in HIV-infected and HIV-uninfecte...