Document Detail


Transduction of biochemical signals across cell membranes.
MedLine Citation:
PMID:  16600054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biological cells need to be responsive to various stimuli, primarily chemical ligands from their environments. Specific receptor molecules embedded in the plasma membrane detect the different biochemical signals that impact the cell, and these receptors are the conduits for transmission of this information to the cell interior for action. There are several classes of signal transduction receptors and many specific receptors within each of the major classes. This review emphasizes the structural biology of three major classes of transmembrane receptors - tyrosine kinase receptors, histidine kinase sensors, and G-protein coupled receptors. Biophysical principles that govern the processes of signal transduction across cell membranes are also discussed.
Authors:
Wayne A Hendrickson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2006-04-06
Journal Detail:
Title:  Quarterly reviews of biophysics     Volume:  38     ISSN:  0033-5835     ISO Abbreviation:  Q. Rev. Biophys.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-11-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0144032     Medline TA:  Q Rev Biophys     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. wayne@convex.hhmi.columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Biophysical Phenomena
Biophysics
Cell Membrane / metabolism*
Lipid Bilayers / metabolism
Models, Biological
Molecular Conformation
Protein Kinases / metabolism
Receptor Protein-Tyrosine Kinases / metabolism
Receptors, G-Protein-Coupled / metabolism
Signal Transduction / physiology*
Thermodynamics
Grant Support
ID/Acronym/Agency:
GM34102/GM/NIGMS NIH HHS; GM68671/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Lipid Bilayers; 0/Receptors, G-Protein-Coupled; EC 2.7.-/Protein Kinases; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.3.-/protein-histidine kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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