| Transdermal scopolamine for the prevention of postoperative nausea and vomiting: a systematic review and meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 21118734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Transdermal scopolamine (TDS) is a potential long-acting prophylactic antiemetic initially developed to prevent motion sickness. TDS is a centrally acting anticholinergic agent that was approved in 2001 by the US Food and Drug Administration for the prevention of postoperative nausea and vomiting (PONV). Although TDS has been reported to be clinically efficacious in the prevention of PONV, several adverse events (AEs), such as sedation, dry mouth, blurred vision, central cholinergic syndrome, and confusion (particularly in elderly patients with mild cognitive impairment), are potential concerns. OBJECTIVE: The aim of this study was to explore the efficacy and tolerability of TDS in the prevention of PONV in adults. METHODS: A systematic search of PubMed, EMBASE, and the Cochrane Library for randomized controlled trials in adults that compared the effects of TDS and placebo on postoperative nausea, vomiting, and PONV was conducted in March 2009, and an update was conducted in July 2010. Without any language restrictions, a search with the following terms was performed: postoperative, postoperative, postanesthe*, postanaesthe*, post-anesthe*, post-anaesthe*, anesthesia, anaesthesia, surgery, surgeries, surgical, nausea, vomiting, emesis, retching, scopolamine, and hyoscine. Identified studies were then hand-searched for further relevant literature. RESULTS: Data from 25 randomized controlled trials were analyzed (N = 3298). In the postanesthesia care unit, TDS was associated with a significantly reduced risk for postoperative nausea compared with placebo (relative risk [RR] = 0.77; 95% CI, 0.61-0.98; P = 0.03). TDS was also associated with a significantly reduced risk for postoperative nausea (RR = 0.59; 95% CI, 0.48-0.73; P < 0.001), postoperative vomiting (RR = 0.68; 95% CI, 0.61-0.76; P < 0.001), and PONV (RR = 0.73; 95% CI, 0.60-0.88; P = 0.001) during the first 24 hours after the start of anesthesia. TDS appeared to be effective compared with placebo in the prevention of postoperative nausea when treatment was initiated the night before (early application) (RR = 0.56; 95% CI, 0.41-0.75; P < 0.001) or on the day of surgery (late application) (RR = 0.61; 95% CI, 0.47-0.79; P < 0.001). TDS was associated with a higher prevalence of visual disturbances at 24 to 48 hours compared with placebo (RR = 3.35; 95% CI, 1.78-6.32). Analyses of confusion and other AEs did not show a significant association with TDS. CONCLUSIONS: In this systematic review and metaanalysis, TDS was associated with significant reductions in PONV with both early and late patch application during the first 24 hours after the start of anesthesia. TDS was associated with a higher prevalence of visual disturbances at 24 to 48 hours after surgery, but no other AEs, compared with placebo. |
| | |
Authors:
|
Christian C Apfel; Kun Zhang; Elizabeth George; Serena Shi; Leena Jalota; Cyrill Hornuss; Katherine E Fero; Felix Heidrich; Joseph V Pergolizzi; Ozlem S Cakmakkaya; Peter Kranke |
Related Documents
:
|
23545664 - Comparison of the efficacies of irbesartan and olmesartan after successful coronary ste... 11815884 - Long-term immunosuppressive treatment of serpiginous choroiditis. 23515684 - Solifenacin improves double-j stent-related symptoms in both genders following uncompli... 23314254 - Segmentation error and macular thickness measurements obtained with spectral-domain opt... 22733244 - The randomized shortened dental arch study: tooth loss over five years. 19142694 - Correction of arthrogrypotic clubfoot with a modified ponseti technique. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Review |
Journal Detail:
|
Title: Clinical therapeutics Volume: 32 ISSN: 1879-114X ISO Abbreviation: Clin Ther Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-12-01 Completed Date: 2011-03-11 Revised Date: 2011-04-04 |
Medline Journal Info:
|
Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 1987-2002 Citation Subset: IM |
Affiliation:
|
Perioperative Clinical Research Core, Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94115, USA. apfelc@anesthesia.ucsf.edu or apfel@ponv.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Antiemetics / administration & dosage, adverse effects, therapeutic use* Humans Postoperative Nausea and Vomiting / chemically induced, prevention & control* Scopolamine / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Antiemetics; 51-34-3/Scopolamine |
| Comments/Corrections | |
Erratum In:
|
Clin Ther. 2010 Dec;32(14):2502 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Integration of proteomic analyses to monitor the activity status of phosphorylation signaling.
Next Document: Efficacy and tolerability of first-line triple therapy with levofloxacin and amoxicillin plus esomep...