Document Detail

Transdermal patch drug delivery interactions with exercise.
MedLine Citation:
PMID:  21395361     Owner:  NLM     Status:  MEDLINE    
Transdermal drug delivery systems, such as the transdermal patch, continue to be a popular and convenient way to administer medications. There are currently several medications that use a transdermal patch drug delivery system. This article describes the potential untoward side effects of increased drug absorption through the use of a transdermal patch in individuals who exercise or participate in sporting events. Four studies have been reported that demonstrate a significant increase in the plasma concentration of nitroglycerin when individuals exercise compared with rest. Likewise, several case reports and two studies have been conducted that demonstrate nicotine toxicity and increased plasma nicotine while wearing a nicotine patch in individuals who exercise or participate in sporting events compared with rest. Healthcare providers, trainers and coaches should be aware of proper transdermal patch use, especially while exercising, in order to provide needed information to their respective patients and athletes to avoid potential untoward side effects. Particular caution should be given to individuals who participate in an extreme sporting event of long duration. Further research that includes more medications is needed in this area.
Thomas L Lenz; Nicole Gillespie
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sports medicine (Auckland, N.Z.)     Volume:  41     ISSN:  1179-2035     ISO Abbreviation:  Sports Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-07-15     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  8412297     Medline TA:  Sports Med     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Copyright Information:
© 2011 Adis Data Information BV. All rights reserved.
Department of Pharmacy Practice, Creighton University, Omaha, Nebraska 68178, USA.
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MeSH Terms
Exercise / physiology*
Nicotine / administration & dosage,  pharmacokinetics
Nicotinic Agonists / administration & dosage,  pharmacokinetics
Nitroglycerin / administration & dosage,  pharmacokinetics
Patient Education as Topic
Skin Absorption / physiology
Transdermal Patch / adverse effects*
Vasodilator Agents / administration & dosage,  pharmacokinetics
Reg. No./Substance:
0/Nicotinic Agonists; 0/Vasodilator Agents; 54-11-5/Nicotine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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