Document Detail

Transdermal oestrogen for postmenopausal women: a double blind crossover comparative study with ethinyl oestradiol.
MedLine Citation:
PMID:  2562605     Owner:  NLM     Status:  MEDLINE    
A double blind crossover study of transdermal oestradiol (50 micrograms/day) and ethinyl oestradiol (20 micrograms/day) was conducted with 25 postmenopausal women. Transdermal oestradiol increased circulating levels of oestradiol and oestrone. Both preparations favourably improved patients' symptoms and vaginal cytology, lowered gonadotrophin levels and urinary calcium loss and gave a satisfactory menstrual pattern. Transdermal oestradiol had no effect on measures of hepatic function whereas oral ethinyl oestradiol significantly altered levels of sex hormone binding globulin, plasma renin substrate and lipoproteins. Transdermal oestradiol has a comparable beneficial effect on postmenopausal symptoms to ethinyl oestradiol without the adverse effects on hepatic proteins.
N S Pattison; T Uptin; B Knox; J France
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  29     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  62-5     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Auckland, National Women's Hospital.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Double-Blind Method
Estradiol / administration & dosage*,  blood
Estrogen Replacement Therapy*
Estrone / blood
Ethinyl Estradiol / administration & dosage*,  therapeutic use
Liver / drug effects
Liver Function Tests
Menopause / drug effects*
Middle Aged
Patient Compliance
Reg. No./Substance:
50-28-2/Estradiol; 53-16-7/Estrone; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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