Document Detail

Transdermal nicotine patch enhances type I collagen synthesis in abstinent smokers.
MedLine Citation:
PMID:  16808802     Owner:  NLM     Status:  MEDLINE    
Cigarette smokers deposit less collagen, expressed as hydroxyproline, in granulation tissue than nonsmokers. We studied the effect of abstinence from smoking and transdermal nicotine patches on deposition of hydroxyproline, proline, type I procollagen, and total proteins. Fifty-four healthy smokers were studied during 10 days of smoking and again from days 10 to 20 following smoking cessation. After the first 10 days of abstinence they were randomized to double-blind treatment with transdermal nicotine patches of 25 mg/day or placebo for a period of 10 days. During this period and during smoking, an expanded polytetrafluoroethylene tube was implanted into the subcutis. Following removal of the implant, total amino acids and peptides were extracted. Hydroxyproline and proline were analyzed by high-pressure liquid chromatography, type I procollagen was analyzed by enzyme-linked immunoassay, and total proteins were determined colorimetrically. In the 39 subjects who complied with the study protocol, abstinence from smoking did not affect the deposition of hydroxyproline, proline, type I procollagen, or total protein in the implants. During abstinence, the type I procollagen level increased by 18% in the transdermal nicotine patches group and decreased by 10% in the placebo group (p<0.05). We conclude that 20 days of abstinence from smoking does not affect collagen deposition in granulation tissue. However, in abstinent smokers, transdermal nicotine patches appears to increase type I collagen synthesis.
Lars T Sørensen; Lars N Jorgensen; Rikke Zillmer; Jakob Vange; Ulla Hemmingsen; Finn Gottrup
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society     Volume:  14     ISSN:  1067-1927     ISO Abbreviation:  Wound Repair Regen     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9310939     Medline TA:  Wound Repair Regen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Copenhagen Wound Healing Center, and Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Administration, Cutaneous
Chromatography, High Pressure Liquid
Collagen Type I / biosynthesis*
Double-Blind Method
Enzyme-Linked Immunosorbent Assay
Hydroxyproline / biosynthesis
Nicotine / administration & dosage*,  therapeutic use
Proline / biosynthesis
Smoking / metabolism
Smoking Cessation*
Wound Healing / drug effects*
Reg. No./Substance:
0/Collagen Type I; 147-85-3/Proline; 51-35-4/Hydroxyproline; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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