Document Detail


Transdermal nicotine mimics the smoking-induced endothelial dysfunction.
MedLine Citation:
PMID:  10976548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cigarette smoking is a major risk factor for coronary artery disease and causes endothelial dysfunction, perhaps by decreasing the availability of nitric oxide availability in arteries and veins. Nicotine in cigarette smoke may be responsible for this impaired endothelial response. METHODS: We studied nine healthy nonsmokers and 12 healthy mild to moderate smokers by use of the dorsal hand vein compliance technique. Dose-response curves to bradykinin and sodium nitroprusside were obtained to test the endothelium-dependent and endothelium-independent vasorelaxation before and during the use of a nicotine (21 mg) patch. Mean arterial blood pressure and heart rate were measured beat-to-beat during the 4-hour study and serial blood samples were drawn to assay plasma thromboxane B2 levels. RESULTS: Transdermal nicotine reduced the venous responsiveness to bradykinin in nonsmokers (Emax = 88.0% +/- 17.9% and 54.3% +/- 14.9%, respectively, before and after the nicotine patch; P < .05); the latter response was similar to that in smokers (Emax = 56.3% +/- 16.6%). Sodium nitroprusside-induced venodilation was unaltered. Mean arterial blood pressure increased in both smokers and nonsmokers. Transdermal nicotine increased the plasma thromboxane B2 concentrations only among nonsmokers. CONCLUSION: These findings indicate that nicotine can have a major role in the impaired endothelial function in smokers. The results probably also reflect what occurs in arterial beds because the nicotine patches increased the mean arterial blood pressure in both smokers and nonsmokers.
Authors:
M Sabha; J E Tanus-Santos; J C Toledo; M Cittadino; J C Rocha; H Moreno
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  68     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Blood Pressure / drug effects
Bradykinin / pharmacology
Cross-Over Studies
Drug Interactions
Endothelium, Vascular / drug effects*,  physiology
Female
Heart Rate / drug effects
Humans
Male
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology*
Nitroprusside / pharmacology
Smoking / blood,  pathology*,  physiopathology
Thromboxane B2 / blood
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Nicotinic Agonists; 15078-28-1/Nitroprusside; 54-11-5/Nicotine; 54397-85-2/Thromboxane B2; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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