| Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial. | |
| | |
MedLine Citation:
|
PMID: 12518122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Pancreatic sphincter hypertension increases the risk of pancreatitis in patients undergoing ERCP. Glyceryl trinitrate reduces sphincter of Oddi pressure. This study tested the hypothesis that transdermal glyceryl trinitrate could be effective in the prevention of post-ERCP pancreatitis. METHODS: One hundred forty-four patients undergoing ERCP were randomized: 71 received a 15-mg glyceryl trinitrate patch (glyceryl trinitrate group) and 73 a placebo patch (control group). RESULTS: In the control group, post-ERCP pancreatitis developed in 11 patients versus 3 in the glyceryl trinitrate group (p < 0.05). Twenty-four hour to baseline serum amylase and lipase ratios were lower in the glyceryl trinitrate group (respectively, 3.6 vs. 7.5, p < 0.05; and 5.3 vs. 27.7, p < 0.05). In a multivariate analysis, glyceryl trinitrate patch and the number of pancreatic injections, but not endoscopic sphincterotomy, were independent risk factors for post-ERCP pancreatitis. CONCLUSIONS: The results of this study suggest that use of a transdermal glyceryl trinitrate patch protects against post-ERCP pancreatitis. |
| | |
Authors:
|
Manuel Moretó; Manuel Zaballa; Ignacio Casado; Olga Merino; Miguel Rueda; Kléber Ramírez; Raquel Urcelay; Amaia Baranda |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Gastrointestinal endoscopy Volume: 57 ISSN: 0016-5107 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2003-01-08 Completed Date: 2003-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
|
Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
|
Servicio de Gastroenterología, Hospital de Cruces, Barakaldo, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Aged Amylases / blood Cholangiopancreatography, Endoscopic Retrograde / adverse effects*, methods Double-Blind Method Endpoint Determination Female Humans Lipase / blood Male Multivariate Analysis Nitroglycerin / therapeutic use* Pancreatitis / blood, etiology, prevention & control* Postoperative Complications Risk Factors Sphincter of Oddi / drug effects Treatment Outcome Vasodilator Agents / administration & dosage*, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 55-63-0/Nitroglycerin; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases |
| Comments/Corrections | |
Comment In:
|
Gastrointest Endosc. 2003 Dec;58(6):940; author reply 940-1
[PMID:
14682304
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of lipoprotein-a on thrombolytic therapy and spontaneous reperfusion in acute myocardial ...
Next Document: Systematic evaluation of complications related to endoscopy in a training setting: A prospective 30-...