Document Detail

Transdermal dopaminergic stimulation with rotigotine in Parkinsonian akinetic crisis.
MedLine Citation:
PMID:  19056273     Owner:  NLM     Status:  MEDLINE    
Akinetic crisis (AC) is a much-feared complication of Parkinson's disease (PD) which may appear upon abrupt cessation or malabsorption of dopaminergic medication due to gastrointestinal tract disorders or acute surgery. Intravenous infusion of amantadine sulphate or subcutaneous administration of apomorphine are established treatment strategies for AC. We speculate whether the use of a non-invasive transdermal application form (patch) of a dopaminergic drug (rotigotine) may represent a useful alternative treatment option. We describe the successful treatment of severe AC using rotigotine in a PD patient with gastro-oesophageal ulcers which precluded administration of any oral medication. This case demonstrates that a rotigotine patch might be effective in the treatment of AC. We suggest that rotigotine may represent a useful treatment option due to its favourable receptor profile and unique application form. In particular, it may be helpful in situations that might provoke AC, such as acute surgery. However, experience of the use of the rotigotine patch in this clinical setting is rather sparse and the patch is currently not approved for this indication.
Manuel Dafotakis; Roland Sparing; Agnes Juzek; Frank Block; Christoph M Kosinski
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-12-03
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  16     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  335-7     Citation Subset:  IM    
Institute of Neuroscience and Biophysics - Medicine, Research Centre Jülich, Leo-Brandt-Str. 1, D-52428 Jülich, Germany.
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MeSH Terms
Administration, Cutaneous
Dopamine Agonists / administration & dosage*
Malabsorption Syndromes / drug therapy*,  etiology
Middle Aged
Parkinsonian Disorders / complications,  psychology
Severity of Illness Index
Tetrahydronaphthalenes / administration & dosage*
Thiophenes / administration & dosage*
Reg. No./Substance:
0/Dopamine Agonists; 0/Tetrahydronaphthalenes; 0/Thiophenes; 92206-54-7/N 0437

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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