Document Detail


Transdermal delivery of theophylline to premature infants using a hydrogel disc system.
MedLine Citation:
PMID:  2350529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Preterm infants show incompletely developed skin with reduced barrier function. The possibility of transdermal delivery of theophylline from hydrogel discs swollen with choline theophyllinate has been investigated. 2. Drug loaded hydrogel discs 2 cm2 in area were applied to the abdomen and occluded. Serum theophylline concentrations were measured in twenty-one infants of less than 31 weeks gestation. 3. Therapeutic concentrations were achieved in 18 individuals, and maintained for up to 15 days after repeated application of discs. A correlation between maximum serum drug concentration and transepidermal water loss, gestation and birthweight was demonstrated.
Authors:
R G Cartwright; P H Cartlidge; N Rutter; C D Melia; S S Davis
Related Documents :
10685239 - The effect of application of aquaphor on skin condition, fluid requirements, and bacter...
3152829 - Etiology and pathophysiology of diaper dermatitis.
10594759 - Barrier formation in the human fetus is patterned.
22563219 - Longitudinal study on trace mineral compositions (selenium, zinc, copper, manganese) in...
3984719 - Congenital self-healing reticulohistiocytoma. a clinical, histological and ultrastructu...
18001159 - Congenital cerebellar malignant rhabdoid tumor in an infant with junctional epidermolys...
6402999 - Leigh's necrotizing encephalopathy with pyruvate carboxylase deficiency.
9548029 - Developmental patterns of heart rate and variability in infants with persistent apnea o...
16456409 - Effect of maternal consumption of lactobacillus gg on transfer and establishment of fec...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  29     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-9     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, University of Nottingham.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Choline / administration & dosage,  analogs & derivatives*,  pharmacology
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Male
Theophylline / administration & dosage*,  analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
146-71-4/cholinophyllin; 58-55-9/Theophylline; 62-49-7/Choline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of nicardipine on the pharmacokinetics and pharmacodynamics of propranolol in healthy volu...
Next Document:  The effect of food and bile acid administration on the relative bioavailability of cyclosporin.