Document Detail


Transdermal delivery of theophylline to premature infants using a hydrogel disc system.
MedLine Citation:
PMID:  2350529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Preterm infants show incompletely developed skin with reduced barrier function. The possibility of transdermal delivery of theophylline from hydrogel discs swollen with choline theophyllinate has been investigated. 2. Drug loaded hydrogel discs 2 cm2 in area were applied to the abdomen and occluded. Serum theophylline concentrations were measured in twenty-one infants of less than 31 weeks gestation. 3. Therapeutic concentrations were achieved in 18 individuals, and maintained for up to 15 days after repeated application of discs. A correlation between maximum serum drug concentration and transepidermal water loss, gestation and birthweight was demonstrated.
Authors:
R G Cartwright; P H Cartlidge; N Rutter; C D Melia; S S Davis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  29     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-9     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, University of Nottingham.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Choline / administration & dosage,  analogs & derivatives*,  pharmacology
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Male
Theophylline / administration & dosage*,  analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
146-71-4/cholinophyllin; 58-55-9/Theophylline; 62-49-7/Choline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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