| Transdermal delivery of salbutamol sulphate: formulation and evaluation. | |
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MedLine Citation:
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PMID: 19519194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salbutamol patches were prepared and evaluated. The effect of different Eudragits and various plasticizers on the properties of the patches were studied. Patches were prepared by casting method employing different plasticizers. These patches were evaluated for weight, thickness uniformity, swelling index, tensile strength, elongation percent and moisture absorption capacity. Release was studied. Tensile strength of the patches using Eudragit RS 100 as well as RS100 + L100 and triacetin was the lowest. Formulae containing 10% oleic acid and 5% dimethyl formamide, respectively, showed the highest permeability. These two formulae were studied clinically, the first formula only showed a significant improvement. |
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Authors:
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Nashwa A El-Gendy; Nirmeen A Sabry; Mai El-Attar; Emad Omar; Manal Mahmoud |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmaceutical development and technology Volume: 14 ISSN: 1097-9867 ISO Abbreviation: Pharm Dev Technol Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-12 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610932 Medline TA: Pharm Dev Technol Country: England |
Other Details:
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Languages: eng Pagination: 216-25 Citation Subset: IM |
Affiliation:
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Pharmaceutics Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt. nash_gend@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adult Albuterol / administration & dosage*, chemistry, pharmacokinetics, therapeutic use* Animals Asthma / drug therapy* Bronchodilator Agents / administration & dosage*, chemistry, pharmacokinetics, therapeutic use* Drug Delivery Systems / methods* Female Humans Male Mice Plasticizers / administration & dosage, chemistry Polymethacrylic Acids / administration & dosage, chemistry Skin / metabolism Solubility Tensile Strength |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 0/Plasticizers; 0/Polymethacrylic Acids; 18559-94-9/Albuterol; 25086-15-1/methylmethacrylate-methacrylic acid copolymer |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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