Document Detail


Transdermal clonidine therapy in elderly mild hypertensives: effects on blood pressure, plasma norepinephrine and fasting plasma glucose.
MedLine Citation:
PMID:  3868715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty patients aged 60-74 years entered a study on the effect of transdermal clonidine (Catapres-TTS) as monotherapy for mild hypertension [diastolic blood pressure (DBP) 90-104 mmHg]. Seventeen patients (85%) had a positive therapeutic response (DBP reduced to less than 90 mmHg or by greater than or equal to 5 mmHg). Patient acceptance was high and side effects mild; however, one-quarter of the patients experienced localized skin reactions. A slight increase in fasting plasma glucose level (mean delta = 20 mg/dl) was consistently observed. Transdermal clonidine led to a sustained decline in plasma catecholamine levels although this effect did not seem to be closely related to the observed decreases in blood pressure. Three out of four evaluable patients had a blood pressure 'overshoot' upon discontinuation of therapy to levels above pretreatment values. Transdermal clonidine appears to be effective and generally well tolerated in the treatment of mild hypertension in the elderly; however, more studies designed to investigate effects on glucose tolerance and the possible existence of a rebound syndrome are needed.
Authors:
C Klein; N Morton; S Kelley; S Metz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  3     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S81-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Aged
Blood Glucose / metabolism*
Blood Pressure / drug effects*
Clonidine / administration & dosage*,  adverse effects,  blood
Dermatitis, Contact / etiology
Female
Humans
Hypertension / blood,  drug therapy*
Male
Middle Aged
Norepinephrine / blood*
Grant Support
ID/Acronym/Agency:
M 01 RR00051-24/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 4205-90-7/Clonidine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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