Document Detail

Transdermal clonidine skin reactions.
MedLine Citation:
PMID:  11927798     Owner:  NLM     Status:  MEDLINE    
The clonidine transdermal therapeutic system is being used as a therapy for blood pressure treatment. Systemic side effects seem to be fewer than with oral clonidine. However, localized skin reactions occur frequently and the incidence increases with the dose and duration of use. Common signs include erythema, scaling, vesiculation, excoriation, and induration. Allergic contact dermatitis is less frequent but common. Hyperpigmentation and depigmentation also occur. Pretreatment with 0.5% hydrocortisone is associated with less skin irritation and higher blood levels. Although oral clonidine is no longer widely used in the management of hypertension, awareness of these reactions to the transdermal delivery of this agent is important.
L Michael Prisant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  4     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-04-02     Completed Date:  2002-04-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-8     Citation Subset:  IM    
Copyright Information:
(c)2002 Le Jacq Communications, Inc.
Department of Medicine, Section of Cardiology, Hypertension Unit, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA.
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MeSH Terms
Adrenergic alpha-Agonists / adverse effects*
Antihypertensive Agents / adverse effects*
Clonidine / adverse effects*
Drug Eruptions / diagnosis,  etiology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Antihypertensive Agents; 4205-90-7/Clonidine

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