Document Detail

Transdermal clonidine compared with hydrochlorothiazide as monotherapy in elderly hypertensive males.
MedLine Citation:
PMID:  2715369     Owner:  NLM     Status:  MEDLINE    
Sixteen of 22 elderly male patients (aged 60-74 years) who had previously taken only hydrochlorothiazide 50 mg completed a study evaluating the safety, efficacy, and tolerability of 12-20 weeks of transdermal clonidine (Catapres TTS) as monotherapy for mild hypertension. Thirteen of the sixteen patients (81%) responded to transdermal clonidine which was begun after 28 days of placebo. Five patients discontinued transdermal clonidine therapy because of intolerable skin irritation, and one because of daytime fatigue. Clonidine caused none of the metabolic effects we observed with hydrochlorothiazide: no change in serum potassium, uric acid, cholesterol, or triglyceride. Eleven of the 22 patients (50%) who began the study experienced a skin reaction under the transdermal clonidine patch. The incidence of dry mouth and fatigue in patients using transdermal clonidine was dose-related and similar to reports of dry mouth and fatigue in patients taking oral clonidine tablets. Rebound hypertension occurred in one patient upon withdrawal of transdermal clonidine. There was no effect of transdermal clonidine or hydrochlorothiazide on cognitive function or emotional state tested with three questionnaires. Overall, transdermal clonidine, in various doses, was as effective as hydrochlorothiazide in elderly male hypertensive patients. The effectiveness of both was inversely proportional to the level of untreated blood pressure. The high incidence of skin reactions limited prolonged use of transdermal clonidine in our patients.
G R Schmidt; A A Schuna; T L Goodfriend
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  29     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-15     Completed Date:  1989-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
William Middleton Memorial Veterans Administration Hospital, Madison, WI.
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MeSH Terms
Administration, Cutaneous
Blood Pressure / drug effects
Clonidine / administration & dosage,  adverse effects,  therapeutic use*
Heart Rate / drug effects
Hydrochlorothiazide / administration & dosage,  adverse effects,  therapeutic use*
Hypertension / drug therapy*,  physiopathology
Middle Aged
Quality of Life
Reg. No./Substance:
4205-90-7/Clonidine; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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