Document Detail


Transdermal administration of emedastine.
MedLine Citation:
PMID:  7903575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transdermal administration of emedastine was tested in vitro and in vivo. In the diffusion cell method in vitro, emedastine free base was more permeable by transdermal administration than emedastine difumarate. Emedastine had higher permeability in hydrophobic vehicles than in hydrophilic vehicles, and was most permeable in fatty acid monoesters. It was suggested that the change in permeability of emedastine from these vehicles was dependent on the change in its partition from the vehicle to the skin. In studies using rabbits in vivo, emedastine had high permeability from fatty acid monoesters and fatty acid diesters as found in in vitro studies, and bioavailability of the drug after transdermal administration was greater than that after peroral administration. The flux of emedastine in vitro was correlative with the pharmacokinetic parameters in vivo. Consequently, it is clear that transdermal permeability of emedastine is very high and that the drug may be efficacious in the system after administration by these means.
Authors:
S Harada; Y Takahashi; H Nakagawa
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  16     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-02-03     Completed Date:  1994-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  884-8     Citation Subset:  IM    
Affiliation:
Pharmaceuticals Research Center, Kanebo Ltd., Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Administration, Oral
Animals
Benzimidazoles / administration & dosage*,  blood,  pharmacokinetics
Buffers
Chromatography, High Pressure Liquid
Histamine H1 Antagonists / administration & dosage*,  blood,  pharmacokinetics
Hydrogen-Ion Concentration
Male
Ointments
Rabbits
Rats
Skin Absorption*
Vehicles
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Buffers; 0/Histamine H1 Antagonists; 0/Ointments; 0/Vehicles; 87233-61-2/emedastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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