| Transdermal Nitroglycerin In Patients With Severe Preeclampsia With Placental Insufficiency: Effect On Doppler Velocimetry Of The Uterine, Umbilical And Middle Cerebral Arteries. | |
| | |
MedLine Citation:
|
PMID: 21374750 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the effect of transdermal nitroglycerin on Doppler velocity waveforms of the uterine, umbilical and middle cerebral arteries in patients with severe preeclampsia. METHOD: This was a prospective study of 30 singleton pregnancies with severe preeclampsia and abnormal uterine and umbilical artery Doppler waveforms (gestational age range: 24 to 31 weeks). We compared maternal blood pressure as well as resistance (RI) and pulsatility indices (PI) of the uterine, umbilical and middle cerebral (MCA) arteries before and after application of a transdermal nitroglycerin patch (average dose 0.4 mg/hr) for a period of 3 days. Intra-day comparisons before and after nitroglycerin administration and a comparison between days 0 (no patch) and 3 after the first dose of nitroglycerin were performed using analysis of variance (ANOVA) for paired samples. RESULTS: A significant decrease in the PI and RI of the uterine (25.3 +/- 4.9% and 21.2 +/- 6.2%, respectively, P<0.001) and umbilical arteries (23.1 +/- 6.9% and 19.7 +/- 6.1%, respectively, P<0.001) was noted when comparing the first day without medication against the third day with the patch. No significant change in the PI and RI of the middle cerebral artery was observed. The mean arterial blood pressure decreased from 119.5 +/- 4.5 to 114.8 +/- 4.4 mmHg (P<0.05). CONCLUSION: The use of transdermal nitroglycerin in patients with severe preeclampsia is associated with a significant reduction in the RI and PI of the uterine and umbilical arteries, as well as maternal blood pressure. Transdermal nitroglycerin did not affect the RI and PI of the middle cerebral artery. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
| | |
Authors:
|
Trapani Alberto; Gonçalves Luis Flávio; Pires Maria Marlene de Souza |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-4 |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Hospital of Federal University of Santa Catarina, Florianópolis, SC, Brazil. ginecoalberto@yahoo.com.br. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypoplastic left heart syndrome with restrictive atrial septum and advanced heart block documented w...
Next Document: Surface area measurement using rendered three dimensional ultrasound imaging: an in vitro phantom st...