Document Detail


Transdermal HRT and Doppler findings in normotensive and hypertensive postmenopausal patients.
MedLine Citation:
PMID:  16184506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effects of transdermal hormone replacement therapy (HRT) on plasma viscosity, serum levels of thromboxane B2 (TXB2) and vascular impedance in the uterine, bladder wall, internal carotid and ophthalmic arteries in normotensive and hypertensive postmenopausal patients. METHODS: Thirty postmenopausal patients underwent continuous estradiol transdermal supplementation at a dose of 50 microg/day and 12-day courses of medroxyprogesterone acetate 10 mg/day every 2 months. The women were divided into two groups according to their blood pressure: normotensive women (Group 1, n=14) and hypertensive subjects (Group 2, n=16). Before starting HRT and after 6 months of therapy, the patients underwent: transvaginal ultrasonographic examination of the pelvic organs; Doppler examination of the blood flow velocities in the uterine, bladder wall, internal carotid and ophthalmic arteries; and analysis of plasma viscosity and plasma TXB2. RESULTS: After 6 months of HRT plasma viscosity had decreased in both groups (mean reduction in Group 1, (14+/-1)%, P=0.005; mean reduction in Group 2, (10+/-1)%, P=0.005) as had the TXB2 levels (mean reduction in Group 1, (93+/-2)%, P<0.001; mean reduction in Group 2, (92+/-3)%, P<0.001). The mean percentage reduction in plasma viscosity was smaller in hypertensive women than in normotensive women (P<0.05). There was also a significant reduction in vascular impedance in the uterine artery (mean reduction in Group 1, (16+/-1)%, P=0.005; mean reduction in Group 2, (19+/-1)%, P=0.005), the bladder wall arteries (mean reduction in Group 1, (23+/-2)%, P=0.005; mean reduction in Group 2, (18+/-1)%, P=0.005), the internal carotid artery (mean reduction in Group 1, (25+/-1)%, P=0.005; mean reduction in Group 2, (26+/-1)%, P=0.005) and the ophthalmic artery (mean reduction in Group 1, (24+/-2)%, P=0.005; mean reduction in Group 2, (16+/-1)%, P=0.005). The percentage reduction in vascular impedance did not differ significantly between the two groups. CONCLUSIONS: Our results show that transdermal HRT is effective in reducing plasma viscosity, TXB2 levels and vascular impedance in the peripheral and central vessels both in normotensive and hypertensive postmenopausal patients.
Authors:
N Persico; F Mancini; P G Artini; P de Iaco; A Volpe; D de Aloysio; C Battaglia
Related Documents :
14688176 - The effects of post-surgical administration of goserelin plus anastrozole compared to g...
22798186 - A dual-institution randomized controlled trial of remnant closure after distal pancreat...
2108196 - Effect of hcg or hcg+ treatments in young thalassemic patients with hypogonadotropic hy...
10515676 - Comparison of transdermal estradiol and tibolone for the treatment of oophorectomized w...
6357576 - Bromocriptine improves reduced libido and potency in men receiving maintenance hemodial...
21711446 - Fibrinogen replacement therapy for congenital fibrinogen deficiency.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  26     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2006-02-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 ISUOG.
Affiliation:
Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Analysis of Variance
Arteries
Blood Viscosity / drug effects
Carotid Artery, Internal / physiopathology
Case-Control Studies
Estradiol / administration & dosage
Estrogen Replacement Therapy*
Female
Humans
Hypertension / blood,  drug therapy,  ultrasonography*
Linear Models
Medroxyprogesterone Acetate / administration & dosage
Middle Aged
Ophthalmic Artery / physiopathology
Postmenopause / blood*
Regional Blood Flow / drug effects
Thromboxane B2 / blood
Ultrasonography, Doppler*
Urinary Bladder / blood supply
Uterus / blood supply
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 54397-85-2/Thromboxane B2; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prenatal diagnosis of fetal hydrometrocolpos secondary to a cloacal anomaly by magnetic resonance im...
Next Document:  Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: does it matter?