Document Detail


Transcutaneous vaccines--current and emerging strategies.
MedLine Citation:
PMID:  23316778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Vaccination, which is the major fundamental prophylaxis against illness and death from infectious disease, has greatly contributed to the global improvement of human health. However, the disadvantages of conventional injection systems hamper the delivery of vaccination technologies to developing countries. The imminent practice of easy-to-use vaccination methods is expected to overcome certain issues associated with injectable vaccinations. One innovative method is the transcutaneous immunization (TCI) system.
AREAS COVERED: Two major strategies for TCI are discussed in this review. One is to promote antigen permeation of the skin barrier by patch systems or nanoparticles. The other is the delivery of antigens into the skin by electroporation and microneedles in order to physically overcome the skin barrier. Moreover, adjuvant development for TCI is discussed.
EXPERT OPINION: Many different approaches have been developed for TCI, which have the potential to be effective, easy-to-use and painless methods of vaccination. However, in practical terms, the guidelines concerning the manufacturing processes and clinical trial evaluation of the procedures have not kept pace with the development of these novel formulations. The accumulation of information regarding skin characteristics and the properties of TCI devices will help refine TCI system development guidelines and thus lead to the improvement of transcutaneous vaccination.
Authors:
Sachiko Hirobe; Naoki Okada; Shinsaku Nakagawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-15
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-05-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  485-98     Citation Subset:  IM    
Affiliation:
Osaka University, Graduate School of Pharmaceutical Sciences, Laboratory of Biotechnology and Therapeutics, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / administration & dosage
Administration, Cutaneous
Animals
Antigens / administration & dosage,  immunology
Chemistry, Pharmaceutical
Developing Countries
Electroporation
Humans
Immunization / methods
Nanoparticles / administration & dosage
Skin / immunology
Technology, Pharmaceutical / trends*
Transdermal Patch*
Vaccination / methods*
Vaccines / administration & dosage*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antigens; 0/Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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