| Transcutaneous theophylline collection in preterm infants. | |
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MedLine Citation:
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PMID: 2328550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transcutaneous collection of theophylline and its metabolite, caffeine, was undertaken in 33 preterm infants (2 to 89 days old) who were receiving routine theophylline therapy. Collection was done by means of a novel adhesive transcutaneous collection system. The transcutaneous collection system accumulated substances that migrated from the blood to the skin surface by trapping them in an activated charcoal-gel matrix. On one to three occasions, four transdermal collection systems were applied to the back or abdomen of each infant for 4 to 12 hours. During that time, blood samples were obtained for routine monitoring of plasma theophylline levels. Amounts of theophylline (95 +/- 198 ng) and caffeine (83 +/- 77 ng) in the transcutaneous collection system were significantly correlated with the respective average plasma drug concentration and postconceptional age (p less than 0.01). Skin reactions were limited to mild erythema. We concluded that theophylline and caffeine can be collected on the surface of the skin of preterm infants with a novel transcutaneous collection system. Amounts collected by means of the transcutaneous collection system correlated with plasma concentrations consistent with a diffusion process, but they were poor predictors of individual concentrations. |
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Authors:
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M G Murphy; C C Peck; D P Conner; K Zamani; G B Merenstein; D Rodden |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 47 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-25 Completed Date: 1990-05-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 427-34 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Caffeine / blood, pharmacokinetics Diffusion Humans Infant, Newborn Infant, Premature / metabolism* Lung Diseases / metabolism Methods Permeability Skin / metabolism* Theophylline / blood, pharmacokinetics* |
| Grant Support | |
ID/Acronym/Agency:
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RR-69/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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