| Transcutaneous bilirubin nomogram for predicting neonatal hyperbilirubinemia in healthy term and late-preterm Chinese infants. | |
| | |
MedLine Citation:
|
PMID: 20814696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Identifying infants that will develop significant hyperbilirubinemia with the risk of kernicterus, and planning appropriate follow-up strategies, is particularly challenging. In this study, 36,921 transcutaneous bilirubin (TcB) measurements were obtained from 6,035 healthy neonates (gestational age ≥ 35 weeks and birth weight ≥ 2,000 g) between January 1 and December 31, 2009. All measurements were performed with the JM-103 bilirubinometer at designated times between 0 and 168 postnatal hours. TcB percentiles were calculated and used to develop an hour-specific nomogram. The rate of increase in TcB was higher during the first 72 h of age, after which levels declined to a plateau by 72-108 h of age. We constructed a TcB nomogram by using the 40th, 75th, and 95th percentile values of TcB for every 12 h of the studied interval. The 75th percentile curve of the nomogram may be an ideal cutoff point for intensive follow-up of the neonate for hyperbilirubinemia as it carries very high sensitivity (78.7%) and negative predictive value (98.5%). The specificity (45.7%) and positive predictive value (15.5%) decreased to reach their lowest levels at the 40th percentile. Of the neonates in the high-risk zone, 167 (48.8%) infants had persistent subsequent hyperbilirubinemia post-discharge, compared with 292 (27.0%) infants in the high-intermediate-risk zone at discharge. One-hundred and seventeen (5.5%) infants in the low-intermediate-risk zone moved into the high-risk zone during follow-up. No newborn infants in the low-risk zone became high-risk during follow-up. We provide an hour-specific TcB nomogram to predict neonatal hyperbilirubinemia in healthy term and late-preterm Chinese infants. |
| | |
Authors:
|
Zhang-Bin Yu; Xiao-Yue Dong; Shu-Ping Han; Yu-Lin Chen; Yu-Fang Qiu; Li Sha; Qing Sun; Xi-Rong Guo |
Related Documents
:
|
9628306 - Combination of abo blood group incompatibility and glucose-6-phosphate dehydrogenase de... 2738726 - Significance of anti-a and anti-b isohemagglutinins in cord blood of abo incompatible n... 633026 - Intermediate phototherapy in the treatment of jaundice in the premature infant. 6683136 - Direct hyperbilirubinemia complicating abo hemolytic disease of the newborn. 18432026 - New and improved israeli reference of birth weight, birth length, and head circumferenc... 23490036 - Cognitive impairment at age 5 years in very preterm infants born following premature ru... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-03 |
Journal Detail:
|
Title: European journal of pediatrics Volume: 170 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-18 Completed Date: 2011-06-30 Revised Date: 2011-11-28 |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
|
Languages: eng Pagination: 185-91 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China. zhangbinyu@njmu.edu.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bilirubin
/
metabolism* Birth Weight China / epidemiology Cohort Studies Female Gestational Age Humans Hyperbilirubinemia, Neonatal / diagnosis*, epidemiology, metabolism Infant Infant, Newborn Infant, Premature / metabolism* Male Nomograms* Predictive Value of Tests Sensitivity and Specificity Skin / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
|
635-65-4/Bilirubin |
| Comments/Corrections | |
Comment In:
|
Eur J Pediatr. 2011 Nov;170(11):1485; author reply 1487
[PMID:
21698400
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term follow-up of a supradescemetic keratoprosthesis in rabbits: an immunofluorescence study.
Next Document: Individual and social predictors of screen-viewing among Spanish school children.