| Transcriptomic comparison of the retina in two mouse models of diabetes. | |
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MedLine Citation:
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PMID: 20157355 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice through chemical toxins or can arise spontaneously from genetic mutations. Both models are associated with retinal vascular and neuronal changes. Retinal transcriptomic responses in C57BL/6J mice treated with streptozotocin and Ins2(Akita/+) were compared after 3 months of hyperglycemia. Specific gene expression changes suggest a neurovascular inflammatory response in diabetic retinopathy. Genes common to the two models may represent the response of the retina to hyperglycemia, while changes unique to each model may represent time-dependent disease progression differences in the various models. Further investigation of the commonalities and differences between mouse models of type I diabetes may define cause and effect events in early diabetic retinopathy disease progression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12177-009-9045-3) contains supplementary material, which is available to authorized users. |
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Authors:
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Willard M Freeman; Georgina V Bixler; Robert M Brucklacher; Erin Walsh; Scot R Kimball; Leonard S Jefferson; Sarah K Bronson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-12-12 |
Journal Detail:
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Title: Journal of ocular biology, diseases, and informatics Volume: 2 ISSN: 1936-8445 ISO Abbreviation: - Publication Date: 2009 |
Date Detail:
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Created Date: 2010-2-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101310837 Medline TA: J Ocul Biol Dis Infor Country: - |
Other Details:
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Languages: ENG Pagination: 202-213 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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