Document Detail


Transcriptome analysis of the effects of gomisin a on the recovery of carbon tetrachloride-induced damage in rat liver.
MedLine Citation:
PMID:  21826177     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Gomisin A possesses a hepatic function-facilitating property in liver-injured rats. Its preventive action on carbon tetrachloride-induced cholestasis is due to maintenance of the function of the bile acids-independent fraction. To investigate alterations in gene expression after gomisin A treatment on injured rat liver, DNA microarray analyses were performed on a Rat 44K 4-Plex Gene Expression platform with duplicated reactions after gomisin A treatment. We identified 255 up-regulated and 230 down-regulated genes due to the effects of gomisin A on recovery of carbon tetrachloride-induced rat liver damage. For functional characterization of these genes, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biochemical pathways analyses were performed. Many up-regulated or down-regulated genes were related to cell cycle or focal adhesion and cell death genes, respectively. Our microarray experiment indicated that the liver repair mechanism induced by gomisin A was strongly associated with increased gene expressions related to cell cycle and suppression of the gene expression related in cell death.
Authors:
Young Mi Choi; In Soo Choi; Sang Mong Lee; Dae Youn Hwang; Young Whan Choi; Young Hoon Park
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Publication Detail:
Type:  Journal Article     Date:  2011-06-22
Journal Detail:
Title:  Laboratory animal research     Volume:  27     ISSN:  2233-7660     ISO Abbreviation:  Lab Anim Res     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-09     Completed Date:  2011-11-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101560684     Medline TA:  Lab Anim Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  161-9     Citation Subset:  -    
Affiliation:
Department of Horticultural Bioscience, College of Natural Resource & Life Science, Pusan National University, Miryang, Republic of Korea.
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