| Transcriptome analysis of adrenocortical cancers (ACC): from molecular classification to the identification of new treatments. | |
| | |
MedLine Citation:
|
PMID: 21208995 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Transcriptome analysis has been successfully used to study the gene profile expression of adrenocortical tumors (ACT) for 7 years. The various studies reported to date have produced an abundance of new information on adrenocortical cancer (ACC), underlying the validity of this approach to study the molecular genetics and pathogenesis of these tumors. The gene expression profile of ACC clearly differs from that of benign adrenocortical adenomas (ACA). Interestingly, transcriptome analysis has the ability to establish a subclassification of ACC based on the gene expression profile. In particular, it is able to identify two groups of tumors with different outcomes (i.e., good prognosis and poor prognosis). This approach has been used to develop molecular markers for ACC diagnosis and prognostication. An insulin-like growth factor 2 (IGF2) cluster of genes upregulated in ACC has been identified. Transcriptome analysis has shown that, in comparison with ACA, IGF2 is indeed the gene most overexpressed in ACC. By contrast, genes associated with steroidogenesis are downregulated in ACC. Genes controlling the cell cycle are dysregulated in ACC, and several are dramatically overexpressed. Analysis regarding the level of expression of Wnt/β-catenin and p53 signaling has shown alterations, in keeping with the known molecular somatic genetic defects of these pathways that are observed in ACC. This review summarizes the main findings of studies reporting ACC transcriptome analysis, demonstrating its power for ACT classification, and examines the resulting progress in understanding the pathogenesis of ACC. The potential for both ACC diagnosis and the identification of new therapeutic targets will be discussed. |
| | |
Authors:
|
Bruno Ragazzon; Guillaume Assié; Jérôme Bertherat |
Related Documents
:
|
23612715 - Evolution of the eye transcriptome under constant darkness in sinocyclocheilus cavefish. 10754105 - High-resolution fish mapping of the rat alpha2u-globulin multigene family. 11393655 - Organization of the chemokine genes in the human and mouse major clusters of cc and cxc... 21418565 - Gene discovery in triatoma infestans. 2931375 - Mapping of a cloned glucosyltransferase gene in streptococcus mutans. 10328985 - Disruption, replacement, and cosuppression of nitrate assimilation genes in stagonospor... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-5 |
Journal Detail:
|
Title: Endocrine-related cancer Volume: - ISSN: 1479-6821 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9436481 Medline TA: Endocr Relat Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
B Ragazzon, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Variation in thyroid function in subclinical hypothyroidism. Importance for clinical follow-up and t...
Next Document: Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secr...