| Transcriptome analyses of bovine, porcine and equine endometrium during the pre-implantation phase. | |
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MedLine Citation:
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PMID: 22917876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Different reproductive strategies evolved in various mammalian groups to achieve recognition, establishment and maintenance of pregnancy. The complexity of these processes is reflected by a high incidence of embryonic loss during this critical period in many mammalian species. Besides studies in mice and humans a number of transcriptome studies of endometrial tissue samples and also of early embryos have been performed during the pre-implantation phase in cattle, swine and horse to identify genes associated with embryo-maternal interaction. Results of these studies are reviewed and compared between species. The comparison of data sets from different species indicated a general role of interferons for the establishment of pregnancy. In addition to many species-specific changes in gene expression, which may reflect different pregnancy recognition signals and mechanisms of embryo implantation, a number of transcriptome changes were found to be similar across species. These genes may have conserved roles during the establishment of pregnancy in mammals and reflect basic principles of mammalian reproduction. The relevance and strategies, but also the challenges of cross-species comparisons of gene expression data are discussed. |
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Authors:
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Stefan Bauersachs; Eckhard Wolf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-08-11 |
Journal Detail:
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Title: Animal reproduction science Volume: 134 ISSN: 1873-2232 ISO Abbreviation: Anim. Reprod. Sci. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-17 Completed Date: 2013-02-13 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 7807205 Medline TA: Anim Reprod Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 84-94 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Molecular Animal Breeding & Biotechnology and Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany. bsachs@genzentrum.lmu.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / physiology* Cattle Embryonic Development / physiology* Endometrium / metabolism* Female Gene Expression Regulation / physiology* Horses Pregnancy Pregnancy, Animal / physiology* Swine Transcriptome* |
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