| Transcriptional targets of p53 that regulate cellular proliferation. | |
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MedLine Citation:
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PMID: 17361486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In response to various forms of cellular stress, including DNA damage, ribonucleotide depletion, and abnormal proliferative signals, p53 becomes activated as a transcription factor, targeted genes that induce cell-cycle arrest and apoptosis. Eliminating damaged, stressed, or abnormally proliferating cells from the replicating cell population prevents the propagation of potentially cancer-prone cells. Here we focus on the transcriptional targets of p53 that regulate the cell cycle. p53 Induction of G1/ S cell-cycle arrest is largely attributed to the transcriptional upregulation of p21WAF1, and more recently, to the transcriptional repression of c-MYC. The role of p53 in G2/M cell-cycle arrest in response to DNA damage is more complex, involving multiple targets that can generally be considered to impinge upon either the cell cycle (e.g., Cyclin-B, cdc2, cdc25C) or the mitotic machinery (i.e., Topoisomerase II, B99/Gtse-1, and MAP4). The ability of p53 to regulate these two type of gene targets may reflect p53-mediated early versus late events in the G2/M cell-cycle arrest response. Together the information presented illustrates the need for further studies to precisely delineate the nature of G2/M cell-cycle arrest in response to cell stress, and defines the role of p53 in what is likely an important mechanism of tumor suppression. |
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Authors:
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Lauren Brown; Sarah Boswell; Lakshmi Raj; Sam W Lee |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical reviews in eukaryotic gene expression Volume: 17 ISSN: 1045-4403 ISO Abbreviation: Crit. Rev. Eukaryot. Gene Expr. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-15 Completed Date: 2007-04-17 Revised Date: 2007-07-11 |
Medline Journal Info:
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Nlm Unique ID: 9007261 Medline TA: Crit Rev Eukaryot Gene Expr Country: United States |
Other Details:
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Languages: eng Pagination: 73-85 Citation Subset: IM |
Affiliation:
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Cutaneous Biology Research Center, Massachussetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics* Cell Cycle Proteins / genetics* Cell Proliferation Humans Mice Rats Transcription, Genetic* Tumor Suppressor Protein p53 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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