| Transcriptional repressors: multifaceted regulators of gene expression. | |
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MedLine Citation:
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PMID: 23293282 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Through decades of research it has been established that some chromatin-modifying proteins can repress transcription, and thus are generally termed 'repressors'. Although classic repressors undoubtedly silence transcription, genome-wide studies have shown that many repressors are associated with actively transcribed loci and that this is a widespread phenomenon. Here, we review the evidence for the presence of repressors at actively transcribed regions and assess what roles they might be playing. We propose that the modulation of expression levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tuning that drives development. |
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Authors:
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Nicola Reynolds; Aoife O'Shaughnessy; Brian Hendrich |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 140 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 505-12 Citation Subset: IM |
Affiliation:
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Wellcome Trust - Medical Research Council Stem Cell Institute, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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