Document Detail


Transcriptional repressors: multifaceted regulators of gene expression.
MedLine Citation:
PMID:  23293282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Through decades of research it has been established that some chromatin-modifying proteins can repress transcription, and thus are generally termed 'repressors'. Although classic repressors undoubtedly silence transcription, genome-wide studies have shown that many repressors are associated with actively transcribed loci and that this is a widespread phenomenon. Here, we review the evidence for the presence of repressors at actively transcribed regions and assess what roles they might be playing. We propose that the modulation of expression levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tuning that drives development.
Authors:
Nicola Reynolds; Aoife O'Shaughnessy; Brian Hendrich
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-07     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  505-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatin / genetics,  metabolism
Chromatin Immunoprecipitation
DNA-Binding Proteins / genetics,  metabolism
DNA-Directed RNA Polymerases / genetics,  metabolism
Embryonic Stem Cells / cytology,  metabolism
Enzyme Activation
Histone Deacetylases / genetics,  metabolism*
Lysine / metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex / genetics,  metabolism
Mice
Repressor Proteins / genetics,  metabolism*
Transcription Factors / genetics,  metabolism
Transcription, Genetic*
Transcriptional Activation
Grant Support
ID/Acronym/Agency:
098021//Wellcome Trust; //Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Chromatin; 0/DNA-Binding Proteins; 0/Mbd3 protein, mouse; 0/Repressor Proteins; 0/Transcription Factors; EC 2.7.7.6/DNA-Directed RNA Polymerases; EC 3.5.1.98/Histone Deacetylases; EC 3.5.1.98/Mi-2 Nucleosome Remodeling and Deacetylase Complex; K3Z4F929H6/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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