Document Detail

Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53.
MedLine Citation:
PMID:  16112647     Owner:  NLM     Status:  MEDLINE    
The eukaryotic initiation factor 4E (eIF4E) plays important roles in transformation and cancer progression. It is frequently overexpressed in malignant cells, one mechanism of which is through transcriptional activation by c-myc. Here, we report that high level of eIF4E expression and its tumorigenicity could be alternatively associated with defects of p53, since we found that induction of wt-p53 repressed eIF4E expression. Gene transfection of p53 inhibited eIF4E promoter activity, while inactivation of p53 either by mutation or by over-expression of MDM2 resulted in stimulation of eIF4E promoter activity. We demonstrated that p53-repression of eIF4E was regulated by c-myc. The wt-p53 can physically bind to c-myc, which inhibited binding of c-myc to eIF4E promoter and c-myc-stimulated promoter activity. These results suggest that the expression of eIF4E is reciprocally regulated by p53 and c-myc, and loss of p53-mediated control over c-myc-dependent transactivation of eIF4E may represent a novel mechanism for eIF4E-mediated neoplastic transformation and cancer progression.
Ningxi Zhu; Lubing Gu; Harry W Findley; Muxiang Zhou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  335     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-11-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1272-9     Citation Subset:  IM    
Division of Pediatric Hematology/Oncology/BMT, Emory University School of Medicine, Atlanta, GA, USA.
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MeSH Terms
Cell Line, Tumor
Eukaryotic Initiation Factor-4E / metabolism*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
Transcription Factors / metabolism*
Transcriptional Activation*
Tumor Suppressor Protein p53 / metabolism*
Grant Support
Reg. No./Substance:
0/Eukaryotic Initiation Factor-4E; 0/Transcription Factors; 0/Tumor Suppressor Protein p53

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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