Document Detail

Transcriptional regulation of vertebrate cardiac morphogenesis.
MedLine Citation:
PMID:  11909814     Owner:  NLM     Status:  MEDLINE    
Transcription factors can regulate the expression of other genes in a tissue-specific and quantitative manner and are thus major regulators of embryonic developmental processes. Several transcription factors that regulate cardiac genes specifically have been described, and the recent discovery that dominant inherited transcription factor mutations cause congenital heart defects in humans has brought direct medical relevance to the study of cardiac transcription factors in heart development. Although this field of study is extensive, several major gaps in our knowledge of the transcriptional control of heart development still exist. This review will concentrate on recent developments in the field of cardiac transcription factors and their roles in heart formation.
Benoit G Bruneau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  90     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-22     Completed Date:  2002-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-19     Citation Subset:  IM    
Division of Cardiovascular Research and Programme in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
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MeSH Terms
Cell Differentiation
Gene Expression Regulation, Developmental / physiology*
Heart / embryology*
Heart Conduction System / embryology
Heart Defects, Congenital / etiology
Myocardium / metabolism*
Signal Transduction / physiology
Transcription Factors / metabolism*
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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