| Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes. | |
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MedLine Citation:
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PMID: 19004619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peptidylarginine deiminase (PAD, EC 3.5.3.15) enzyme catalyzes the conversion of arginine residues to citrulline residues in the presence of calcium ion, which is an elaborate post-translational modification on the target protein. Recently, five isoforms have been identified in mammals. Among them, three isoforms (type I, II, III) are expressed in the human epidermis, and involved in several skin physiological and pathological processes. In the past few years, several researches concerning the transcriptional regulation of three human PADI type genes (PADI1, PADI2 and PADI3) in the epidermis have been carried out. In this review, we describe an overview of the current outcomes about these studies with their significance. It is anticipated that these investigations will provide novel therapeutic and prophylactic targets for future approaches to the treatment or prevention of severe psoriasis and bullous congenital ichthyosiform erythroderma. |
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Authors:
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Shibo Ying; Sijun Dong; Akira Kawada; Toshio Kojima; Stéphane Chavanas; Marie-Claire Méchin; Véronique Adoue; Guy Serre; Michel Simon; Hidenari Takahara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-11-11 |
Journal Detail:
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Title: Journal of dermatological science Volume: 53 ISSN: 0923-1811 ISO Abbreviation: J. Dermatol. Sci. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011485 Medline TA: J Dermatol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2-9 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Resource Sciences, School of Agriculture, Ibaraki University, Inashiki-gun, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Homeostasis / genetics Humans Hydrolases / genetics*, metabolism* Isoenzymes / genetics, metabolism Keratinocytes / cytology, metabolism* Molecular Sequence Data Skin Physiological Phenomena / genetics Transcription, Genetic / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 3.-/Hydrolases; EC 3.5.3.15/protein-arginine deiminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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