| Transcriptional regulation of macrophage polarization: enabling diversity with identity. | |
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MedLine Citation:
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PMID: 22025054 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease. |
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Authors:
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Toby Lawrence; Gioacchino Natoli |
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Publication Detail:
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Type: Journal Article Date: 2011-10-25 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: 11 ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 750-61 Citation Subset: IM |
Affiliation:
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Centre d'Immunologie Marseille-Luminy, Parc Scientifique & Technologique de Luminy, Case 906, F-13288 Marseille, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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