| Transcriptional regulation in the immune system: all roads lead to AP-1. | |
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MedLine Citation:
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PMID: 9468273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms regulating the development and function of the immune system are diverse and complicated. The signaling pathways and target genes that become activated upon cell-surface stimulation are currently being defined, and transcription factor activator protein 1 (AP-1) is proving to be an important regulator of nuclear gene expression in leukocytes. In vitro and in vivo studies have demonstrated that AP-1 expression is induced after a diverse range of stimuli and that AP-1 contributes to the regulation of a large number of genes. In this review we will examine the role of AP-1 during leukocyte activation and differentiation in the immune system. |
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Authors:
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V C Foletta; D H Segal; D R Cohen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 63 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-02-26 Completed Date: 1998-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 139-52 Citation Subset: IM |
Affiliation:
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Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4068, USA. torie@codon.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation Apoptosis B-Lymphocytes / physiology* Cell Differentiation Cytokines / genetics Gene Expression Regulation, Developmental Humans Lymphocyte Activation Protein Binding Receptors, Antigen, B-Cell / physiology* Receptors, Antigen, T-Cell / physiology* Signal Transduction T-Lymphocytes / physiology* Thymus Gland / cytology Transcription Factor AP-1 / physiology* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Receptors, Antigen, B-Cell; 0/Receptors, Antigen, T-Cell; 0/Transcription Factor AP-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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