| Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases. | |
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MedLine Citation:
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PMID: 7483327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Steroid hormone biosynthesis requires the concerted action of a related group of cytochrome P-450 steroid hydroxylases. In recent years considerable effort has been directed toward defining the molecular basis for the cell-selective expression of these genes and their transcriptional regulation by trophic hormones. The orphan nuclear receptor SF-1, acting through a conserved element found in the proximal promoter regions of all steroid hydroxylase genes, seems to be a major, but not exclusive, determinant of cell-selective gene expression. In contrast, the coordinate responses of the steroid hydroxylases to trophic hormones apparently involves an interplay of multiple proteins that collectively lead to a synchronous induction of gene expression. In some instances these interactions apparently involve transcription factors that also contribute to the cell-selective expression of these genes. |
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Authors:
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K L Parker; B P Schimmer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Vitamins and hormones Volume: 51 ISSN: 0083-6729 ISO Abbreviation: Vitam. Horm. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-12-21 Completed Date: 1995-12-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413601 Medline TA: Vitam Horm Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 339-70 Citation Subset: IM |
Affiliation:
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Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyclic AMP Response Element-Binding Protein Cytochrome P-450 Enzyme System / genetics* DNA-Binding Proteins Fushi Tarazu Transcription Factors Gene Expression Regulation* Homeodomain Proteins Humans Organ Specificity Proto-Oncogene Proteins Receptors, Cytoplasmic and Nuclear Steroid Hydroxylases / genetics* Steroidogenic Factor 1 Steroids / biosynthesis Transcription Factors Transcription, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Cyclic AMP Response Element-Binding Protein; 0/DNA-Binding Proteins; 0/Fushi Tarazu Transcription Factors; 0/Homeodomain Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Steroidogenic Factor 1; 0/Steroids; 0/Transcription Factors; 0/pbx1 protein, human; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.-/Steroid Hydroxylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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