Document Detail

Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases.
MedLine Citation:
PMID:  7483327     Owner:  NLM     Status:  MEDLINE    
Steroid hormone biosynthesis requires the concerted action of a related group of cytochrome P-450 steroid hydroxylases. In recent years considerable effort has been directed toward defining the molecular basis for the cell-selective expression of these genes and their transcriptional regulation by trophic hormones. The orphan nuclear receptor SF-1, acting through a conserved element found in the proximal promoter regions of all steroid hydroxylase genes, seems to be a major, but not exclusive, determinant of cell-selective gene expression. In contrast, the coordinate responses of the steroid hydroxylases to trophic hormones apparently involves an interplay of multiple proteins that collectively lead to a synchronous induction of gene expression. In some instances these interactions apparently involve transcription factors that also contribute to the cell-selective expression of these genes.
K L Parker; B P Schimmer
Related Documents :
18508997 - Patterns and changes in gene expression following neo-adjuvant anti-estrogen treatment ...
17666587 - Long-range activation of greb1 by estrogen receptor via three distal consensus estrogen...
23982877 - Association of xrcc5 vntr polymorphism with the development of chronic myeloid leukemia.
2420797 - Thyroid hormone regulation of the transfected rat growth hormone promoter.
23377967 - Microrna target prediction and validation.
11779847 - Cloning and characterization of the human heparanase-1 (hpr1) gene promoter: role of ga...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vitamins and hormones     Volume:  51     ISSN:  0083-6729     ISO Abbreviation:  Vitam. Horm.     Publication Date:  1995  
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413601     Medline TA:  Vitam Horm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-70     Citation Subset:  IM    
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cyclic AMP Response Element-Binding Protein
Cytochrome P-450 Enzyme System / genetics*
DNA-Binding Proteins
Fushi Tarazu Transcription Factors
Gene Expression Regulation*
Homeodomain Proteins
Organ Specificity
Proto-Oncogene Proteins
Receptors, Cytoplasmic and Nuclear
Steroid Hydroxylases / genetics*
Steroidogenic Factor 1
Steroids / biosynthesis
Transcription Factors
Transcription, Genetic*
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein; 0/DNA-Binding Proteins; 0/Fushi Tarazu Transcription Factors; 0/Homeodomain Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Steroidogenic Factor 1; 0/Steroids; 0/Transcription Factors; 0/pbx1 protein, human; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.-/Steroid Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of repeat use and coating defects of gold foil electrodes on electroretinogram recording.
Next Document:  25 years' experience with diagnosis of pheochromocytoma