Document Detail


Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases.
MedLine Citation:
PMID:  7483327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Steroid hormone biosynthesis requires the concerted action of a related group of cytochrome P-450 steroid hydroxylases. In recent years considerable effort has been directed toward defining the molecular basis for the cell-selective expression of these genes and their transcriptional regulation by trophic hormones. The orphan nuclear receptor SF-1, acting through a conserved element found in the proximal promoter regions of all steroid hydroxylase genes, seems to be a major, but not exclusive, determinant of cell-selective gene expression. In contrast, the coordinate responses of the steroid hydroxylases to trophic hormones apparently involves an interplay of multiple proteins that collectively lead to a synchronous induction of gene expression. In some instances these interactions apparently involve transcription factors that also contribute to the cell-selective expression of these genes.
Authors:
K L Parker; B P Schimmer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vitamins and hormones     Volume:  51     ISSN:  0083-6729     ISO Abbreviation:  Vitam. Horm.     Publication Date:  1995  
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413601     Medline TA:  Vitam Horm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-70     Citation Subset:  IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclic AMP Response Element-Binding Protein
Cytochrome P-450 Enzyme System / genetics*
DNA-Binding Proteins
Fushi Tarazu Transcription Factors
Gene Expression Regulation*
Homeodomain Proteins
Humans
Organ Specificity
Proto-Oncogene Proteins
Receptors, Cytoplasmic and Nuclear
Steroid Hydroxylases / genetics*
Steroidogenic Factor 1
Steroids / biosynthesis
Transcription Factors
Transcription, Genetic*
Chemical
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein; 0/DNA-Binding Proteins; 0/Fushi Tarazu Transcription Factors; 0/Homeodomain Proteins; 0/Proto-Oncogene Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Steroidogenic Factor 1; 0/Steroids; 0/Transcription Factors; 0/pbx1 protein, human; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.-/Steroid Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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