Document Detail


Transcriptional regulation of follicular T-helper (Tfh) cells.
MedLine Citation:
PMID:  23405901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-follicular helper (Tfh) cells are a new subset of effector CD4(+) T cells that are specialized in helping B cells in the germinal center reaction. Tfh cells are distinct from other established CD4(+) T-cell lineages, Th1, Th2, Th17, and T-regulatory cells, in their gene expression profiles. Tfh cell differentiation results from a network of transcriptional regulation by a master transcriptional factor Bcl6 as well as IRF4, c-Maf, Batf, and STAT3/5. During Tfh cell ontogeny, increased CXCR5 expression directs activated T-cell migration to the follicles, and their interaction with B cells leads to Bcl6 upregulation, which helps establish effector and memory Tfh cell program. This review summarizes the recent progress in molecular mechanisms underlying Tfh differentiation and discusses the future perspectives for this important area of research.
Authors:
Xindong Liu; Roza I Nurieva; Chen Dong
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-18     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / cytology,  immunology*
Basic-Leucine Zipper Transcription Factors / genetics,  immunology
Cell Lineage / immunology
DNA-Binding Proteins / genetics,  immunology*
Gene Expression Regulation
Germinal Center / cytology,  immunology*
Humans
Interferon Regulatory Factors / genetics,  immunology
Proto-Oncogene Proteins c-maf / genetics,  immunology
Receptors, CXCR5 / genetics,  immunology
STAT Transcription Factors / genetics,  immunology
Signal Transduction
T-Lymphocytes, Helper-Inducer / cytology,  immunology*
Transcription, Genetic*
Grant Support
ID/Acronym/Agency:
R01 AI083761/AI/NIAID NIH HHS; R01 AR050772/AR/NIAMS NIH HHS; RC2 AR059010/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/BATF protein, human; 0/BCL6 protein, human; 0/Basic-Leucine Zipper Transcription Factors; 0/CXCR5 protein, human; 0/DNA-Binding Proteins; 0/Interferon Regulatory Factors; 0/MAF protein, human; 0/Proto-Oncogene Proteins c-maf; 0/Receptors, CXCR5; 0/STAT Transcription Factors; 0/interferon regulatory factor-4
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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