Document Detail

Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors.
MedLine Citation:
PMID:  12489182     Owner:  NLM     Status:  MEDLINE    
Dentin matrix protein 1 (DMP1) is an extracellular matrix phosphoprotein whose expression is precisely controlled temporally and spatially during the differentiation of the odontoblasts. Odontoblasts are postmitotic cells that differentiate to mature polarized cells and are responsible for the synthesis of a calcified dentin matrix. Although the DMP1 promoter has been isolated from the mouse and the rat, little is actually known about their control by specific transcription factors. Analysis of the rat DMP1 promoter has identified several regulatory transcription factors. These factors include AP-1 family members, SP1 and ETS. Therefore the transcription of DMP1 may be controlled positively or negatively by a variety of stimuli resulting in a developmentally regulated gene expression. This study demonstrates the role of c-fos and c-jun on the transcriptional regulation of DMP1 gene.
Karthikeyan Narayanan; Amsaveni Ramachandran; Jianjun Hao; Anne George
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Connective tissue research     Volume:  43     ISSN:  0300-8207     ISO Abbreviation:  Connect. Tissue Res.     Publication Date:  2002  
Date Detail:
Created Date:  2002-12-19     Completed Date:  2003-04-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0365263     Medline TA:  Connect Tissue Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Department of Oral Biology (M/C 690), University of Illinois at Chicago, Chicago, IL 60612, USA.
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MeSH Terms
Binding Sites
Cell Line
Enhancer Elements, Genetic / genetics,  physiology
Extracellular Matrix Proteins
Minerals / metabolism
Mutagenesis, Site-Directed
Phosphoproteins / genetics*,  metabolism
Promoter Regions, Genetic / genetics,  physiology
Proto-Oncogene Proteins c-fos / physiology*
Proto-Oncogene Proteins c-jun / physiology*
Repressor Proteins / genetics
Tooth / metabolism
Transcription Factor AP-1 / physiology*
Transcription Factors / metabolism
Transcription, Genetic / physiology*
Grant Support
Reg. No./Substance:
0/Dmp1 protein, mouse; 0/Extracellular Matrix Proteins; 0/Minerals; 0/Phosphoproteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Repressor Proteins; 0/Transcription Factor AP-1; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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