Document Detail


Transcriptional regulation of catabolic pathways for aromatic compounds in Corynebacterium glutamicum.
MedLine Citation:
PMID:  17183485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corynebacterium glutamicum is a gram-positive soil microorganism able to utilize a large variety of aromatic compounds as the sole carbon source. The corresponding catabolic routes are associated with multiple ring-fission dioxygenases and among other channeling reactions, include the gentisate pathway, the protocatechuate and catechol branches of the beta-ketoadipate pathway and two potential hydroxyquinol pathways. Genes encoding the enzymatic machinery for the bioconversion of aromatic compounds are organized in several clusters in the C. glutamicum genome. Expression of the gene clusters is under specific transcriptional control, apparently including eight DNA-binding proteins belonging to the AraC, IclR, LuxR, PadR, and TetR families of transcriptional regulators. Expression of the gentisate pathway involved in the utilization of 3-hydroxybenzoate and gentisate is positively regulated by an IclR-type activator. The metabolic channeling of ferulate, vanillin and vanillate into the protocatechuate branch of the beta-ketoadipate pathway is controlled by a PadR-like repressor. Regulatory proteins of the IclR and LuxR families participate in transcriptional regulation of the branches of the beta-ketoadipate pathway that are involved in the utilization of benzoate, 4-hydroxybenzoate and protocatechuate. The channeling of phenol into this pathway may be under positive transcriptional control by an AraC-type activator. One of the potential hydroxyquinol pathways of C. glutamicum is apparently repressed by a TetR-type regulator. This global analysis revealed that transcriptional regulation of aromatic compound utilization is mainly controlled by single regulatory proteins sensing the presence of aromatic compounds, thus representing single input motifs within the transcriptional regulatory network of C. glutamicum.
Authors:
K Brinkrolf; I Brune; A Tauch
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-12-07
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  5     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-21     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  773-89     Citation Subset:  IM    
Affiliation:
Institut für Genomforschung, Centrum für Biotechnologie, Universität Bielefeld, Bielefeld, Germany.
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MeSH Terms
Descriptor/Qualifier:
Biodegradation, Environmental
Corynebacterium glutamicum / genetics*,  metabolism*
Gene Expression Regulation, Bacterial / genetics*
Hydrocarbons, Aromatic / metabolism*
Hydroxybenzoic Acids / metabolism*
Transcription, Genetic / genetics*
Chemical
Reg. No./Substance:
0/Hydrocarbons, Aromatic; 0/Hydroxybenzoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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