Document Detail

Transcriptional regulation by human papillomaviruses.
MedLine Citation:
PMID:  16099158     Owner:  NLM     Status:  MEDLINE    
Human papillomaviruses are the causative agent of cancers in stratified epithelial surfaces. They replicate in the upper parts of the epithelium, where cells would normally be dying to produce a cornified layer. Therefore, they need to inhibit or delay differentiation and stimulate cell cycle progression to create an environment conducive for replication of the viral genome. The alterations both in differentiation and in the cell cycle are achieved by the viral proteins E6 and E7, which modulate cellular transcription mainly through their effects on p53 and the retinoblastoma family.
Dennis J McCance
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  15     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
Department of Microbiology & Immunology and the James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA.
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MeSH Terms
Cell Differentiation / physiology
Epithelial Cells / virology
Papillomaviridae / genetics,  physiology*
Transcription, Genetic / physiology*
Viral Proteins / genetics,  physiology
Reg. No./Substance:
0/Viral Proteins

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