| Transcriptional regulation of the PCNA promoter by p53. | |
MedLine Citation:
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PMID: 7915517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the ability of p53 to affect transcription from the PCNA promoter in a number of cell types. In HeLa cells, p53 activates the PCNA promoter whereas in CV1, CHO, L929, and Saos-2 cells the same promoter is strongly repressed. By using stepwise deletions of the PCNA promoter, we have identified two potential regions of the promoter which are important for the ability of p53 to activate transcription in HeLa cells. |
Authors:
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P Jackson; P Ridgway; J Rayner; J Noble; A Braithwaite |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 203 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-09-29 Completed Date: 1994-09-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 133-40 Citation Subset: IM |
Affiliation:
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Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals CHO Cells Cell Line Chloramphenicol O-Acetyltransferase / biosynthesis Cricetinae Gene Expression Regulation* Hela Cells Humans Kinetics L Cells (Cell Line) Mice Nuclear Proteins / genetics* Plasmids Proliferating Cell Nuclear Antigen Promoter Regions, Genetic* Transcription, Genetic* Transfection Tumor Suppressor Protein p53 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nuclear Proteins; 0/Proliferating Cell Nuclear Antigen; 0/Tumor Suppressor Protein p53; EC 2.3.1.28/Chloramphenicol O-Acetyltransferase |
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