Document Detail

Transcriptional regulation of the PCNA promoter by p53.
MedLine Citation:
PMID:  7915517     Owner:  NLM     Status:  MEDLINE    
We have examined the ability of p53 to affect transcription from the PCNA promoter in a number of cell types. In HeLa cells, p53 activates the PCNA promoter whereas in CV1, CHO, L929, and Saos-2 cells the same promoter is strongly repressed. By using stepwise deletions of the PCNA promoter, we have identified two potential regions of the promoter which are important for the ability of p53 to activate transcription in HeLa cells.
P Jackson; P Ridgway; J Rayner; J Noble; A Braithwaite
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  203     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-29     Completed Date:  1994-09-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  133-40     Citation Subset:  IM    
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra.
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MeSH Terms
CHO Cells
Cell Line
Chloramphenicol O-Acetyltransferase / biosynthesis
Gene Expression Regulation*
Hela Cells
L Cells (Cell Line)
Nuclear Proteins / genetics*
Proliferating Cell Nuclear Antigen
Promoter Regions, Genetic*
Transcription, Genetic*
Tumor Suppressor Protein p53 / metabolism*
Reg. No./Substance:
0/Nuclear Proteins; 0/Proliferating Cell Nuclear Antigen; 0/Tumor Suppressor Protein p53; EC O-Acetyltransferase

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