Document Detail

Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.
MedLine Citation:
PMID:  11411255     Owner:  NLM     Status:  MEDLINE    
Bone morphogenetic proteins (BMPs) have been shown to play an important role in cell growth and differentiation. BMPs, a rapidly expanding family closely related to transforming growth factor-beta (TGF-beta) superfamily, have been proven recently to possess a regulatory role and neurotrophic capacity in neurogenesis. The aim of the present study is to reveal the relationship among BMPs, peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP 2, 3, 4 and 5 in 12 cases of schwannoma, four cases of malignant schwannoma and three cases of trigeminal neuralgia were detected using an in situ hybridization technique. Our results demonstrated that the myelin sheaths of schwann cell from the peripheral neuroectomy of trigeminal neuralgia were positively expressing mRNA of BMP-2, 3, 4 and 5. However, the nerve fibers of trigeminal nerve showed only BMP-2 positive staining. All of the neoplastic lesions of nerve sheath showed a consistent but variant expression of BMP-2, 3, 4, and 5. Except for the BMP-4 mRNA, the expression signals of BMP-2, 3 and 5 mRNA in malignant schwannoma were relatively lower than in benign lesions. On the basis of the findings, we concluded that selected members of BMPs existed in the peripheral nerves and might contribute to the health maintenance, proliferation, regeneration and neoplastic transformation of the peripheral nerve system. Moreover, the effects of BMP-2, 3, 4 and 5 on peripheral nerve system and its neoplastic transformation might be widespread, diverse and antagonistic.
C S Tang; Y Jin; K I Cheng; K L Yu; F Suwa; I Nakatsuji; K Makigusa; Y R Fang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Kaohsiung journal of medical sciences     Volume:  17     ISSN:  1607-551X     ISO Abbreviation:  Kaohsiung J. Med. Sci.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-06-19     Completed Date:  2001-07-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100960562     Medline TA:  Kaohsiung J Med Sci     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  16-24     Citation Subset:  IM    
Department of Anesthesiology, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Rd., Kaohsiung, Taiwan.
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MeSH Terms
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 3
Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 5
Bone Morphogenetic Proteins / genetics*
In Situ Hybridization
Middle Aged
Nerve Sheath Neoplasms / metabolism*
RNA, Messenger / analysis*
Transforming Growth Factor beta*
Reg. No./Substance:
0/BMP2 protein, human; 0/BMP3 protein, human; 0/BMP4 protein, human; 0/BMP5 protein, human; 0/Bone Morphogenetic Protein 2; 0/Bone Morphogenetic Protein 3; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Protein 5; 0/Bone Morphogenetic Proteins; 0/RNA, Messenger; 0/Transforming Growth Factor beta

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