| Transcriptional deficits in oxidative phosphorylation with statin myopathy. | |
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MedLine Citation:
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PMID: 21996800 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, or statins, are widely used drugs for hyperlipidemia and are generally well-tolerated, but the can produce skeletal muscle toxicity. The molecular mechanisms driving statin myopathy are unknown. We investigated the effects of statin treatment and eccentric (damaging) exercise on transcriptional patterns between statin myopathy (Sym; N = 9) and statin-tolerant subjects (Asym; N = 6). Methods: Skeletal muscle biopsies were collected 6 h post-exercise at baseline and after statin treatment. Subjects performed concentric (non-damaging) exercise with one leg and concentric + eccentric exercise with the other leg using a cross-over design between time-points. Results: Sym as compared with Asym demonstrated decreased skeletal muscle gene expression for oxidative phosphorylation-related and mitochondrial ribosomal protein genes before and after statin treatment with eccentric exercise. Conclusions: These results suggest that pre-existing deficiencies in energy production may contribute to the development of symptoms during statin therapy, especially when muscle is exposed to eccentric exercise. Muscle Nerve 44: 393-401, 2011. |
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Authors:
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Monica J Hubal; Kimberly A Reich; Andrea De Biase; Cherie Bilbie; Priscilla M Clarkson; Eric P Hoffman; Paul D Thompson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 44 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 393-401 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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