Document Detail

Transcriptional control during mammalian anterior pituitary development.
MedLine Citation:
PMID:  14597167     Owner:  NLM     Status:  MEDLINE    
The mammalian anterior pituitary gland is a compound endocrine organ that regulates reproductive development and fitness, growth, metabolic homeostasis, the response to stress, and lactation, by actions on target organs such as the gonads, the liver, the thyroid, the adrenals, and the mammary gland. The protein and peptide hormones that control these physiological parameters are secreted by specialized pituitary cell types that derive from a common origin in the early ectoderm. Collectively, the broad physiological importance of the pituitary gland, its intriguing organogenesis, and the clinical and agricultural significance of its actions, have established pituitary development as an excellent model system for the study of the gene-regulatory cascades that guide vertebrate cell determination and differentiation. We review the transcriptional pathways that regulate the commitment of the individual pituitary cell lineages and that subsequently modulate trophic hormone gene activity in the differentiated cells of the mature gland.
Jesse J Savage; Benjamin C Yaden; Parinda Kiratipranon; Simon J Rhodes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Gene     Volume:  319     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-04     Completed Date:  2004-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-19     Citation Subset:  IM    
Department of Biology, Indiana University Center for Regenerative Biology and Medicine, Indiana University-Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202-5132, USA.
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MeSH Terms
Gene Expression Regulation, Developmental*
Models, Genetic
Pituitary Gland, Anterior / embryology,  metabolism*
Pituitary Hormones, Anterior / genetics
Transcription Factors / genetics
Transcription, Genetic
Reg. No./Substance:
0/Pituitary Hormones, Anterior; 0/Transcription Factors

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