Document Detail

Transcriptional activities of retinoic acid receptors.
MedLine Citation:
PMID:  15727806     Owner:  NLM     Status:  MEDLINE    
Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid signaling pathway. Retinoids are also therapeutically effective in the treatment of skin diseases (acne, psoriasis and photoaging) and of some cancers. Most of these effects are the consequences of retinoic acid receptors activation, which triggers transcriptional events leading either to transcriptional activation or repression of retinoid-controlled genes. Synthetic molecules are able to mimic part of the biological effects of the natural retinoic acid receptors, all-trans retinoic acid. Therefore, retinoic acid receptors are considered as highly valuable therapeutic targets and limiting unwanted secondary effects due to retinoid treatment requires a molecular knowledge of retinoic acid receptors biology. In this review, we will examine experimental evidence which provide a molecular basis for the pleiotropic effects of retinoids, and emphasize the crucial roles of coregulators of retinoic acid receptors, providing a conceptual framework to identify novel therapeutic targets.
Philippe Lefebvre; Perrine J Martin; Sébastien Flajollet; Stéphane Dedieu; Xavier Billaut; Bruno Lefebvre
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vitamins and hormones     Volume:  70     ISSN:  0083-6729     ISO Abbreviation:  Vitam. Horm.     Publication Date:  2005  
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-06-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413601     Medline TA:  Vitam Horm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-264     Citation Subset:  IM    
INSERM U459 and Ligue Nationale Contre le Cancer, Faculté de Médecine de Lille, 59045 Lille cedex, France.
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MeSH Terms
Congenital Abnormalities
Gene Expression Regulation
Receptors, Retinoic Acid / chemistry,  physiology*
Retinoids / pharmacology,  physiology
Retinol-Binding Proteins / physiology
Transcription Factor AP-1
Transcription, Genetic*
Transcriptional Activation
Vitamin A Deficiency
Reg. No./Substance:
0/Receptors, Retinoic Acid; 0/Retinoids; 0/Retinol-Binding Proteins; 0/Transcription Factor AP-1

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