| Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. | |
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MedLine Citation:
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PMID: 19071119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interplay between hypoxia-inducible factor-1alpha (HIF-1alpha) and histone deacetylase (HDACs) have been well studied; however, the mechanism of cross-talk is unclear. Here, we investigated the roles of HDAC4 and HDAC5 in the regulation of HIF-1alpha function and its associated mechanisms. HDAC4 and HDAC5 enhanced transactivation by HIF-1alpha without stabilizing HIF-1alpha. HDAC4 and HDAC5 physically associated with HIF-1alpha through the inhibitory domain (ID) that is the binding site for factor inhibiting HIF-1 (FIH-1). In the presence of these HDACs, binding of HIF-1alpha to FIH-1 decreased, whereas binding to p300 increased. These results indicate that HDAC4 and HDAC5 increase the transactivation function of HIF-1alpha by promoting dissociation of HIF-1alpha from FIH-1 and association with p300. |
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Authors:
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Hee-Won Seo; Eun-Jin Kim; Hyelin Na; Mi-Ock Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-09 |
Journal Detail:
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Title: FEBS letters Volume: 583 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-29 Completed Date: 2009-03-10 Revised Date: 2011-08-29 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 55-60 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Bio-MAX Institute, Seoul National University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Histone Deacetylases / metabolism* Humans Hypoxia-Inducible Factor 1, alpha Subunit / genetics* Repressor Proteins / metabolism* Transcriptional Activation* p300-CBP Transcription Factors / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Repressor Proteins; EC 1.14.11.-/HIF1AN protein, human; EC 2.3.1.48/p300-CBP Transcription Factors; EC 3.5.1.98/HDAC4 protein, human; EC 3.5.1.98/HDAC5 protein, human; EC 3.5.1.98/Histone Deacetylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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