Document Detail

Transcriptional regulatory cascades in Runx2-dependent bone development.
MedLine Citation:
PMID:  23150948     Owner:  NLM     Status:  MEDLINE    
The development of the musculoskeletal system is a complex process that involves very precise control of bone formation and growth as well as remodeling during postnatal life. Although the understanding of the transcriptional mechanisms of osteogenesis has increased considerably, the molecular regulatory basis, especially the gene regulatory network of osteogenic differentiation, is still poorly understood. This review provides the reader with an overview of the key transcription factors that govern bone formation, highlighting their function and regulation linked to Runt-related transcription factor 2 (Runx2). Runx2 as the master transcription factor of osteoblast differentiation, Twist, Msh homeobox 2 (Msx2), and promyelocytic leukemia zinc-finger protein (PLZF) acting upstream of Runx2, Osterix (Osx) acting downstream of Runx2, and activating transcription factor 4 (ATF4) and zinc-finger protein 521 (ZFP521) acting as cofactors of Runx2 are discussed, and their relevance for tissue engineering is presented. References are provided for more in-depth personal study.
Tong Ming Liu; Eng Hin Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-28
Journal Detail:
Title:  Tissue engineering. Part B, Reviews     Volume:  19     ISSN:  1937-3376     ISO Abbreviation:  Tissue Eng Part B Rev     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-15     Completed Date:  2014-04-15     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101466660     Medline TA:  Tissue Eng Part B Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-63     Citation Subset:  IM    
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MeSH Terms
Bone Development / genetics*
Core Binding Factor Alpha 1 Subunit / genetics,  metabolism*
Gene Expression Regulation*
Osteogenesis / genetics
Transcription, Genetic*
Reg. No./Substance:
0/Core Binding Factor Alpha 1 Subunit

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