Document Detail

Transcriptional regulation in yeast during diauxic shift and stationary phase.
MedLine Citation:
PMID:  20863251     Owner:  NLM     Status:  MEDLINE    
The preferred source of carbon and energy for yeast cells is glucose. When yeast cells are grown in liquid cultures, they metabolize glucose predominantly by glycolysis, releasing ethanol in the medium. When glucose becomes limiting, the cells enter diauxic shift characterized by decreased growth rate and by switching metabolism from glycolysis to aerobic utilization of ethanol. When ethanol is depleted from the medium, cells enter quiescent or stationary phase G(0). Cells in diauxic shift and stationary phase are stressed by the lack of nutrients and by accumulation of toxic metabolites, primarily from the oxidative metabolism, and are differentiated in ways that allow them to maintain viability for extended periods of time. The transition of yeast cells from exponential phase to quiescence is regulated by protein kinase A, TOR, Snf1p, and Rim15p pathways that signal changes in availability of nutrients, converge on transcriptional factors Msn2p, Msn4p, and Gis1p, and elicit extensive reprogramming of the transcription machinery. However, the events in transcriptional regulation during diauxic shift and quiescence are incompletely understood. Because cells from multicellular eukaryotic organisms spend most of their life in G(0) phase, understanding transcriptional regulation in quiescence will inform other fields, such as cancer, development, and aging.
Luciano Galdieri; Swati Mehrotra; Sean Yu; Ales Vancura
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-09-23
Journal Detail:
Title:  Omics : a journal of integrative biology     Volume:  14     ISSN:  1557-8100     ISO Abbreviation:  OMICS     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-03-23     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101131135     Medline TA:  OMICS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-38     Citation Subset:  IM    
Department of Biological Sciences, St. John's University, Queens, New York, USA.
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MeSH Terms
Ethanol / metabolism
Gene Expression Regulation, Fungal* / genetics,  physiology
Glucose / metabolism
Saccharomyces cerevisiae / genetics,  metabolism*
Saccharomyces cerevisiae Proteins / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Saccharomyces cerevisiae Proteins; 50-99-7/Glucose; 64-17-5/Ethanol

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