| Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression. | |
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MedLine Citation:
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PMID: 22355797 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat stimulates transcription elongation by directing the cellular transcriptional elongation factor P-TEFb to nascent RNA polymerases. Rev is required for the transport from the nucleus to the cytoplasm of the unspliced and incompletely spliced mRNAs that encode the structural proteins of the virus. Molecular studies of both proteins have revealed how they interact with the cellular machinery to control transcription from the viral LTR and regulate the levels of spliced and unspliced mRNAs. The regulatory feedback mechanisms driven by HIV-1 Tat and Rev ensure that HIV-1 transcription proceeds through distinct phases. In cells that are not fully activated, limiting levels of Tat and Rev act as potent blocks to premature virus production. |
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Authors:
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Jonathan Karn; C Martin Stoltzfus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cold Spring Harbor perspectives in medicine Volume: 2 ISSN: 2157-1422 ISO Abbreviation: Cold Spring Harb Perspect Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101571139 Medline TA: Cold Spring Harb Perspect Med Country: United States |
Other Details:
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Languages: eng Pagination: a006916 Citation Subset: - |
Affiliation:
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Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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