Document Detail

The transcriptional control of female puberty.
MedLine Citation:
PMID:  20851111     Owner:  NLM     Status:  MEDLINE    
The initiation of mammalian puberty requires a sustained increase in pulsatile release of gonadotrophin releasing hormone (GnRH) from the hypothalamus. This increase is brought about by coordinated changes in transsynaptic and glial-neuronal communication, consisting of an increase in neuronal and glial stimulatory inputs to the GnRH neuronal network and the loss of transsynaptic inhibitory influences. GnRH secretion is stimulated by transsynaptic inputs provided by excitatory amino acids (glutamate) and at least one peptide (kisspeptin), and by glial inputs provided by growth factors and small bioactive molecules. The inhibitory input to GnRH neurons is mostly transsynaptic and provided by GABAergic and opiatergic neurons; however, GABA has also been shown to directly excite GnRH neurons. There are many genes involved in the control of these cellular networks, and hence in the control of the pubertal process as a whole. Our laboratory has proposed the concept that these genes are arranged in overlapping networks internally organized in a hierarchical fashion. According to this concept, the highest level of intra-network control is provided by transcriptional regulators that, by directing expression of key subordinate genes, impose genetic coordination to the neuronal and glial subsets involved in initiating the pubertal process. More recently, we have begun to explore the concept that a more dynamic and encompassing level of integrative coordination is provided by epigenetic mechanisms.
Sergio R Ojeda; Alejandro Lomniczi; Alberto Loche; Valerie Matagne; Gabi Kaidar; Ursula S Sandau; Gregory A Dissen
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-09-17
Journal Detail:
Title:  Brain research     Volume:  1364     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-03-21     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Neurosecretory Systems / physiology
Puberty / genetics*,  physiology
Sexual Maturation / genetics*,  physiology
Transcription, Genetic / physiology*
Grant Support
HD050798/HD/NICHD NIH HHS; HD25123/HD/NICHD NIH HHS; MH65438/MH/NIMH NIH HHS; P51 RR000163/RR/NCRR NIH HHS; P51 RR000163-460082/RR/NCRR NIH HHS; R01 HD025123/HD/NICHD NIH HHS; R01 HD025123-20/HD/NICHD NIH HHS; R01 MH065438/MH/NIMH NIH HHS; R01 MH065438-04/MH/NIMH NIH HHS; RR000163/RR/NCRR NIH HHS; U-54 HD18185/HD/NICHD NIH HHS; U54 HD018185/HD/NICHD NIH HHS; U54 HD018185-25S27989/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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