Document Detail


Transcription and replication: Far relatives make uneasy bedfellows.
MedLine Citation:
PMID:  20519944     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Genomes encode all RNAs required for life. For this simple reason the genome's stability is a prerequisite for maintaining the fitness of the cell, the organism and its progeny. Paradoxically, any enzymatic transaction at the DNA, including transcription itself, entails the risk of local destabilization of the DNA helix, thereby threatening genomic integrity. Particularly where transcription and replication meet, the genome may be at an increased risk of nucleotide substitution mutations, deletions or rearrangements. This Extra-view sketches our understanding of the different threats that transcription imposes on genome stability. We will focus on recent work highlighting the role of DNA damage in transcription-associated mutagenesis (TAM) in mammalian cells. Furthermore we discuss the possible implications of TAM for human fitness and disease with an emphasis on carcinogenesis. In addition, we propose an updated nomenclature for the mechanistically different forms of TAM.
Authors:
Giel Hendriks; Jacob G Jansen; Leon H F Mullenders; Niels de Wind
Related Documents :
15006344 - Visualizing gene expression: an unfolding story.
3684574 - Oligoribonucleotide synthesis using t7 rna polymerase and synthetic dna templates.
12595254 - Visualizing rna extrusion and dna wrapping in transcription elongation complexes of bac...
9336444 - Processing of topoisomerase i cleavable complexes into dna damage by transcription.
15207654 - Free radical scavenging and antioxidant activities of eps2, an exopolysaccharide produc...
10454604 - Layer-by-layer deposition of oppositely charged polyelectrolytes on the surface of cond...
Publication Detail:
Type:  Journal Article     Date:  2010-06-15
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  9     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2300-4     Citation Subset:  IM    
Affiliation:
Leiden University Medical Center; Leiden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transcriptional crosstalk between TGF? and stem cell pathways in tumor cell invasion: Role of EMT pr...
Next Document:  p53 in cytoplasm exerts 3'?5' exonuclease activity with dsRNA.