Document Detail


Transcription regulation coupling of the divergent argG and metY promoters in Escherichia coli K-12.
MedLine Citation:
PMID:  12730174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cAMP-catabolite activator protein (CAP) complex is a pleiotropic regulator that regulates a vast number of Escherichia coli genes, including those involved in carbon metabolism. We identified two new targets of this complex: argG, which encodes the arginosuccinate synthase involved in the arginine biosynthetic pathway, and metY, which encodes one of the two methionine tRNA initiators, tRNAf2Met. The cAMP-CAP complex activates argG transcription and inhibits metY transcription from the same DNA position. We also show that ArgR, the specific repressor of the arginine biosynthetic pathway, together with its arginine cofactor, acts on the regulation of metY mediated by CAP. The regulation of the two divergent promoters is thus simultaneously controlled not only by the cAMP-CAP complex, a global regulator, but also by a specific regulator of arginine metabolism, suggesting a previously unsuspected link between carbon metabolism and translation initiation.
Authors:
Evelyne Krin; Christine Laurent-Winter; Philippe N Bertin; Antoine Danchin; Annie Kolb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bacteriology     Volume:  185     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-05     Completed Date:  2003-06-16     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3139-46     Citation Subset:  IM    
Affiliation:
Unité de Génétique des Génomes Bactériens, Institut Pasteur, 75724 Paris Cedex 15, France. ekrin@pasteur.fr
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Argininosuccinate Synthase / genetics*,  metabolism
Bacterial Proteins / genetics,  metabolism
Base Sequence
Binding Sites
Carbon-Oxygen Lyases / genetics*,  metabolism
Cyclic AMP Receptor Protein / genetics,  metabolism
Cysteine Synthase
Escherichia coli / genetics*,  metabolism
Escherichia coli Proteins / genetics*,  metabolism
Gene Expression Regulation, Bacterial*
Molecular Sequence Data
Multienzyme Complexes*
Mutation
Promoter Regions, Genetic
Repressor Proteins / genetics,  metabolism
Saccharomyces cerevisiae Proteins*
Transcription, Genetic
Chemical
Reg. No./Substance:
0/ArgR protein, Bacteria; 0/ArgR protein, E coli; 0/Bacterial Proteins; 0/Cyclic AMP Receptor Protein; 0/Escherichia coli Proteins; 0/Multienzyme Complexes; 0/Repressor Proteins; 0/Saccharomyces cerevisiae Proteins; EC 2.5.1.47/Cysteine Synthase; EC 2.5.1.47/MET17 protein, S cerevisiae; EC 2.5.1.47/O-acetylhomoserine (thiol)-lyase; EC 4.2.-/Carbon-Oxygen Lyases; EC 6.3.4.5/ArgG protein, E coli; EC 6.3.4.5/Argininosuccinate Synthase
Comments/Corrections

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