Document Detail


Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence.
MedLine Citation:
PMID:  12774316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol abuse is a common human disorder with high rate of comorbidity with other psychiatric disorders. To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P < 0.007, chi(2)test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P < 0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly. The most abundant and consistent changes were in gene families encoding mitochondrial proteins, the ubiquitin system, and signal transduction. These alterations indicate disturbances in energy metabolism and multiple signaling mechanisms in the temporal cortex of subjects with a history of alcohol abuse or dependence. We hypothesize that these mechanisms may be related to alcohol abuse traits or long-term effects of alcohol.
Authors:
Boris P Sokolov; Lixin Jiang; Niraj S Trivedi; Christopher Aston
Related Documents :
11130736 - The relation of personality to alcohol abuse/dependence in a high-risk sample.
20887576 - Intoxigenic digital spaces? youth, social networking sites and alcohol marketing.
10414616 - Dependence, locus of control, parental bonding, and personality disorders: a study in a...
389836 - Patient autonomy in alcohol rehabilitation. i. literature review.
24323176 - How flies respond to honey bee pheromone: the role of the foraging gene on reproductive...
14617996 - Modeling life satisfaction among the aged: a comparison of chinese and americans.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  72     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-29     Completed Date:  2003-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  756-67     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA. BSokolov@intra.nida.nih.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / genetics*,  metabolism
Brain Chemistry / genetics*
Chi-Square Distribution
Female
Gene Expression Profiling / methods*,  statistics & numerical data
Gene Expression Regulation / physiology
Humans
Male
Middle Aged
Mitochondria / genetics*,  metabolism
Oligonucleotide Array Sequence Analysis / methods
Signal Transduction / genetics*
Transcription, Genetic*
Ubiquitin / biosynthesis,  genetics*
Chemical
Reg. No./Substance:
0/Ubiquitin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 1...
Next Document:  Cyclic AMP responsive element binding protein phosphorylation and persistent expression of levodopa-...