| Transcription inhibition: a potential strategy for cancer therapeutics. | |
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MedLine Citation:
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PMID: 16213135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interference with transcription triggers a stress response leading to the induction of the tumour suppressor p53. If transcription is not restored within a certain time frame cells may undergo apoptosis in a p53-dependent and independent manner. The mechanisms by which blockage of transcription induces apoptosis may involve diminished levels of anti-apoptotic factors, inappropriate accumulation of proteins in the nucleus, accumulation of p53 at mitochondria or complications during replication. Many chemotherapeutic agents currently used in the clinic interfere with transcription and this interference may contribute to their anti-cancer activities. Future efforts should be directed towards exploring whether interference of transcription could be used as an anti-cancer therapeutic strategy. |
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Authors:
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Frederick A Derheimer; Ching-Wei Chang; Mats Ljungman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2005-10-05 |
Journal Detail:
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Title: European journal of cancer (Oxford, England : 1990) Volume: 41 ISSN: 0959-8049 ISO Abbreviation: Eur. J. Cancer Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-02 Completed Date: 2005-12-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9005373 Medline TA: Eur J Cancer Country: England |
Other Details:
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Languages: eng Pagination: 2569-76 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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genetics,
physiology Gene Therapy / methods* Humans Neoplasms / therapy* Transcription, Genetic / genetics* Tumor Suppressor Protein p53 / genetics, physiology |
| Grant Support | |
ID/Acronym/Agency:
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CA-82376/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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